AB9533

Anti-HSV1 antibody

Name: Anti-HSV1 antibody (ab9533) | Abcam
Brand: Abcam Limited
SKU: AB9533
Rating: 5 (2 reviews)

(2 Reviews)

(44 Publications)

Anti-HSV1 antibody (ab9533) is a rabbit polyclonal antibody detecting HSV1 in IHC-P. Suitable for Herpes simplex virus.

- Over 30 publications
- Trusted since 2002

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSV1 antibody (AB9533)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSV1 antibody (AB9533)

Formalin-fixed, paraffin-embedded HSV1-infected human tissue stained for HSV1 with ab9533 in immunohistochemical analysis.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSV1 antibody (AB9533)

Formalin-fixed, paraffin-embedded HSV1-infected human tissue stained for HSV1 with ab9533 in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Light chain type

unknown

Carrier free

Reacts with

Herpes simplex virus

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Herpes simplex virus": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p>This antibody may be diluted to a titer of 1:75-1:200 in an ABC method. We suggest an incubation period of 30-60 minutes at room temperature. Pretreat with citrate buffer pH 6.0.</p>" } } }

style

left-column

Product details

What is this antibody validated in?
Anti-HSV1 antibody (ab9533) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Herpes simplex virus samples.

Trusted by the scientific community
Anti-HSV1 (ab9533) was first used in a scientific publication in 2002 and has been cited over 30 times in peer-reviewed journals.

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.3 - 7.5 Preservative: 0.05% Sodium azide Constituents: 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Herpes Simplex Virus 1 (HSV1) also referred to as HSV-1 is an enveloped virus with a large double-stranded DNA genome of about 152 kb. HSV1 possesses a complex architecture featuring numerous glycoproteins including gHSV1 that play significant roles in its entry and immune evasion. This virus predominantly targets epithelial cells in the oral genital regions and sensory neurons. HSV1 expresses various proteins vital for its replication and viral particle assembly within host cells.

Biological function summary

HSV1 interacts with the host's cellular mechanisms to establish latency and persistent infection. During infection several HSV1 proteins contribute to its ability to subvert and evade the host immune response sometimes forming part of existing viral protein complexes. Virion-host cell membrane fusion facilitated by glycoprotein gHSV1 is an important step allowing the viral genome to enter the host cell driving subsequent viral replication.

Pathways

The life cycle of HSV1 includes entry replication and egress tightly integrated into cellular pathways like the apoptosis and the interferon response pathways. HSV1 modulates the apoptotic pathway through proteins such as ICP22 which allows survival and efficient viral replication. Also it influences the interferon response pathway by inhibiting the host's antiviral mechanisms ensuring viral persistence in the host.

HSV1 is most commonly known to cause oral herpes and can lead to encephalitis in severe cases. The virus reactivates from latency within neurons potentially leading to periodic disease recurrence. During infection HSV1 interacts with host proteins such as TNF-alpha which can contribute to inflammatory responses and ICP0 which facilitates viral replication and disrupts host cell function. Understanding HSV1's mechanisms and pathways is critical for developing effective anti-HSV-1 antibodies and therapeutic strategies.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

See full target information HSV1

style

left-column

Publications (44)

Recent publications for all applications. Explore the full list and refine your search

EMBO reports 26:720-747 PubMed39747662

2025

HDAC6 deacetylates TRIM56 to negatively regulate cGAS-STING-mediated type I interferon responses.

Applications

Unspecified application

Species

Unspecified reactive species

Qiongzhen Zeng,Zixin Chen,Shan Li,Ziwei Huang,Zhe Ren,Cuifang Ye,Xiao Wang,Jun Zhou,Kaisheng Liu,Kai Zheng,Yifei Wang

Cell reports. Medicine 5:101528 PubMed38677283

2024

Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Tiphaine Delaunay,Sehee Son,Seongji Park,Balveen Kaur,Jeonghyun Ahn,Glen N Barber

The Journal of dermatology 51:e314-e315 PubMed38587235

2024

Herpes simplex virus infection with a marginal Nikolsky sign in an immunocompromised patient.

Applications

Unspecified application

Species

Unspecified reactive species

Eriko Takayama,Akiko Yoshioka

BMC oral health 24:347 PubMed38500158

2024

HPV related p16 and HSV in benign and potentially malignant oral mucosa pathologies.

Applications

Unspecified application

Species

Unspecified reactive species

Irena Duś-Ilnicka,Agnieszka Hałoń,Andrea Perra,Małgorzata Radwan-Oczko

Virologica Sinica 39:251-263 PubMed38219860

2024

Mice with type I interferon signaling deficiency are prone to epilepsy upon HSV-1 infection.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Yang,Chong-Yang Tang,Dong-Ying Fan,Yi-Song Wang,Pei-Gang Wang,Jing An,Guo-Ming Luan

Investigative ophthalmology & visual science 64:24 PubMed38117245

2023

Loss of TRPM8 Exacerbate Herpes Simplex Keratitis Infection in Mice by Promoting the Infiltration of CD11b+ Ly6G+ Cells and Increasing the Viral Load in the Cornea.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Feng,Lingling Yang,Lili Ran,Xia Qi,Xiaolei Wang,Yangyang Zhang,Zongzheng Zou,Ting Liu,Xiaochuan Wang,Yang Yu,Xiaodong Sun,Qingjun Zhou

Nature communications 14:6132 PubMed37783727

2023

Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoquan Wang,Youqiao Wang,Anqi Cao,Qinhong Luo,Daoyuan Chen,Weiqi Zhao,Jun Xu,Qinkai Li,Xianzhang Bu,Junmin Quan

Frontiers in veterinary science 10:1152920 PubMed37205226

2023

Infection due to Buteo buteo herpesvirus in a common buzzard ().

Applications

Unspecified application

Species

Unspecified reactive species

Cristian M Suárez-Santana,Eva Sierra,Lucía Marrero-Ponce,Ana Colom-Rivero,Jose Navarro-Sarmiento,Simone Segura-Göthlin,Ayoze Castro-Alonso,Óscar Quesada-Canales

Communications medicine 3:40 PubMed36966232

2023

Fusion peptide is superior to co-expressing subunits for arming oncolytic herpes virus with interleukin 12.

Applications

Unspecified application

Species

Unspecified reactive species

Hiroshi Fukuhara,Yuzuri Tsurumaki Sato,Jiangang Hou,Miwako Iwai,Tomoki Todo

Journal of medical virology 95:e28652 PubMed36897017

2023

Repurposing of the antibiotic nitroxoline for the treatment of mpox.

Applications

Unspecified application

Species

Unspecified reactive species

Denisa Bojkova,Nadja Zöller,Manuela Tietgen,Katja Steinhorst,Marco Bechtel,Tamara Rothenburger,Joshua D Kandler,Julia Schneider,Victor M Corman,Sandra Ciesek,Holger F Rabenau,Mark N Wass,Stefan Kippenberger,Stephan Göttig,Martin Michaelis,Jindrich Cinatl

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-HSV1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSV1 antibody (AB9533)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSV1 antibody (AB9533)

Key facts

Host species

Clonality

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (44)

Product promise