Anti-HSV1 gD antibody [1-I-9]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Glycoprotein D facilitates virus entry into the host by interacting with entry mediators. Although gD itself is not part of a larger protein complex its interaction with host cell receptors is essential to trigger downstream events necessary for viral replication. The binding of gD to cellular receptors initiates conformational changes that lead to the fusion of the viral envelope with the cell membrane. This fusion is a critical step in the viral life cycle allowing the viral capsid to enter the host cell cytoplasm and ultimately reach the nucleus for replication.

Pathways

Glycoprotein D is involved in the viral entry pathway coordinating with proteins such as glycoprotein B and glycoprotein H to successfully mediate the fusion process. The role of gD in HSV-1 entry links to pathways that manage cellular response to viral infections particularly engaging immune response mechanisms and signaling pathways involved in membrane fusion and receptor-mediated endocytosis. During its replication cycle HSV1 gD participates in the broader context of herpesvirus entry and spread within host tissues.