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AB226858

Anti-HSV1 + HSV2 antibody

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(3 Publications)

Rabbit Polyclonal HSV1 antibody. Suitable for WB and reacts with Herpes simplex virus, Human herpesvirus 2 samples. Cited in 3 publications. Immunogen corresponding to Virus preparation containing HSV1 protein.

View Alternative Names

Herpes simplex virus, Herpes simplex virus 1, Herpes simplex virus type 1, Human Herpesvirus 1, Human herpesvirus type 1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Herpes simplex virus, Human herpesvirus 2

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Virus preparation containing HSV2 protein.

Specificity

ab226858 is specific for HSV1 and HSV2. It recognizes ICPs and late structural (virion) antigens.

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Reactivity data

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Product details

Concentration is typically 4-5 mg/ml.
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Properties and storage information

Form
Liquid
Purification notes
Purity >95%
Storage buffer
pH: 7.2 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HSV1 and HSV2 short for Herpes Simplex Virus Type 1 and Type 2 are double-stranded DNA viruses with similar structure and function. They are encapsulated with a lipid envelope featuring glycoproteins which are important for viral entry into host cells. These viruses have a capsid housing the viral genome and weigh around 150 kDa. HSV1 and HSV2 are primarily expressed in epithelial tissues and the nervous system specifically in neurons where they establish latency. HSV1 and HSV2 antibodies as well as anti-HSV1 antibodies and anti-HSV2 antibodies target these viruses aiding in research and diagnostics.
Biological function summary

HSV1 and HSV2 have significant roles in viral infection processes. They form complexes with host cell receptors to facilitate adhesion and entry into cells. Their glycoproteins interact with cellular proteins to trigger fusion and facilitate viral replication. During this process the viruses actively modulate the host's immune response enabling the evasion of immune detection. The ability to remain dormant and reactivate is an important aspect of their biology.

Pathways

HSV1 and HSV2 participate in cell entry and immune evasion processes. These viruses exploit the host's cellular machinery via the MAPK signaling pathway and the PI3K/Akt pathway to enhance viral replication and survival. The viral proteins ICP0 and glycoprotein D are essential for modulating these pathways. These interactions impact the immune response and cellular cycle regulation allowing the virus to maintain its presence within the host.

HSV1 and HSV2 are significant contributors to conditions like oral herpes and genital herpes. They are also associated with severe infections such as Herpes Simplex Encephalitis. The HSV1 and HSV2 target proteins through their interaction with host proteins facilitate these infections. Herpes Simplex Virus type-specific antibodies help in detecting and studying these viruses leading to better understanding and treatment of related conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information HSV1

Additional targets

HSV2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Neoplasia (New York, N.Y.) 63:101152 PubMed40096771

2025

Targeting BARD1 suppresses a Myc-dependent transcriptional program and tumor growth in pancreatic ductal adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Sohum Patel,Eleanor Jenkins,Rutuj P Kusurkar,Sherry Lee,Wei Jiang,Avinoam Nevler,Matthew McCoy,Michael J Pishvaian,Rosalie C Sears,Jonathan R Brody,Charles J Yeo,Aditi Jain

Proceedings of the National Academy of Sciences of the United States of America 118: PubMed34417304

2021

A recombinant herpes virus expressing influenza hemagglutinin confers protection and induces antibody-dependent cellular cytotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine Kaugars,Joseph Dardick,Anna Paula de Oliveira,Kayla A Weiss,Regy Lukose,John Kim,Lawrence Leung,Saranathan Rajagopalan,Sydney Wolin,Leor Akabas,David M Knipe,Goran Bajic,William R Jacobs

Molecular therapy oncolytics 20:220-227 PubMed33665360

2021

Oncolytic activity of naturally attenuated herpes-simplex virus HF10 against an immunocompetent model of oral carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Gaku Takano,Shinichi Esaki,Fumi Goshima,Atsushi Enomoto,Yoshimi Hatano,Haruka Ozaki,Takahiro Watanabe,Yoshitaka Sato,Daisuke Kawakita,Shingo Murakami,Takayuki Murata,Yukihiro Nishiyama,Shinichi Iwasaki,Hiroshi Kimura
View all publications
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