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AB21112

Anti-HSV2 antibody

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(4 Publications)

Sheep Polyclonal HSV2 antibody. Suitable for ELISA, WB, Conjugation, ICC/IF, IM and reacts with Human herpesvirus 2 samples. Cited in 4 publications. Immunogen corresponding to Virus preparation containing HSV2 protein.

View Alternative Names

Herpes Simplex Virus Type 2

Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human herpesvirus 2

Applications

WB, Conjugation, IM, ICC/IF, ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "Conjugation" : {"fullname" : "Conjugation", "shortname":"Conjugation"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IM" : {"fullname" : "Immunomicroscopy", "shortname":"IM"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human herpesvirus 2": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "Conjugation-species-checked": "guaranteed", "Conjugation-species-dilution-info": "", "Conjugation-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IM-species-checked": "guaranteed", "IM-species-dilution-info": "", "IM-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Ion exchange chromatography
Purification notes
>95% pure. Sodium sulphate precipitation and ion exchange chromatography.
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Herpes Simplex Virus type 2 (HSV2) also known as Human Herpesvirus 2 is a member of the herpesviridae family. It mainly affects the genital region and is a common cause of genital herpes. The virus has a double-stranded DNA genome with a mass of approximately 152 kbp. HSV2 primarily expresses in epithelial cells of the skin and mucous membranes. It can establish latency in neuronal cells especially the sacral ganglia contributing to its ability to persist in the host for life.
Biological function summary

HSV2 exhibits a complex life cycle involving both lytic and latent phases. During infection the virus interacts with cellular compartments including the nucleus where it hijacks host cell machinery to replicate its genome. In the latent phase HSV2 becomes dormant in sensory neurons avoiding host immune detection. It is not part of a larger complex but relies on numerous viral proteins for successful replication and invasion such as glycoproteins critical for host entry.

Pathways

HSV2 interacts with multiple immune evasion and inflammatory pathways. It manipulates the NF-kB signaling pathway an important player in inflammation and immune responses. The virus evades immune detection by inhibiting the activation of NF-kB allowing persistent infection. HSV2 also affects the MAPK signaling pathway through viral proteins such as ICP34.5 which modulate host defense mechanisms and facilitate viral replication.

HSV2 is significantly associated with genital herpes and is linked to an increased risk of HIV acquisition. Genital herpes can cause recurrent painful lesions and can be transmitted to neonates during childbirth leading to neonatal herpes. The virus's interaction with host immune pathways might also modify the host's susceptibility to other sexually transmitted infections including HIV. HSV2 through its impact on the host's immune response shares interactions with proteins like HIV-1 gp120 in co-infected individuals which complicates the management of these infections.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information HSV2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 13:983502 PubMed36211339

2022

Herpes simplex virus type 2 inhibits TNF-α-induced NF-κB activation through viral protein ICP22-mediated interaction with p65.

Applications

Unspecified application

Species

Unspecified reactive species

Huimin Hu,Ming Fu,Chuntian Li,Binman Zhang,Yuncheng Li,Qinxue Hu,Mudan Zhang

Human gene therapy 33:649-663 PubMed35272497

2022

Bispecific Antibody Expressed by an Oncolytic Herpes Simplex Virus Type 2 Can Transform Heterologous T Cells Into Uniform Tumor Killer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Jin,Runyang Wang,Junhan Yang,Han Hu,Di Wang,Linkang Cai,Zhizheng Fang,Shuang Dong,Sheng Hu,Yang Wang,Binlei Liu

Frontiers in microbiology 10:2790 PubMed31849920

2019

Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2.

Applications

Unspecified application

Species

Unspecified reactive species

Martin Michaelis,Malte C Kleinschmidt,Denisa Bojkova,Holger F Rabenau,Mark N Wass,Jindrich Cinatl

Frontiers in immunology 9:2932 PubMed30619292

2018

Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4 T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4.

Applications

Unspecified application

Species

Unspecified reactive species

Mudan Zhang,Xu Deng,Xinmeng Guan,Lanlan Geng,Ming Fu,Binman Zhang,Rui Chen,Huimin Hu,Kai Hu,Di Zhang,Mei Li,Yalan Liu,Sitang Gong,Qinxue Hu
View all publications
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