Anti-HSV2 gC antibody [H1196]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

HSV2 gC contributes significantly to HSV-2’s pathogenic profile. It is a part of the complex viral machinery that masks the virus from the host immune system. By binding to complement component C3b it impairs the complement cascade reducing opsonization and phagocytosis. This evasion of immune responses permits the virus to efficiently establish infection and persistence within the host. Furthermore the interaction of gC with host cells amplifies virus attachment efficiency facilitating viral transmission and spread.

Pathways

HSV2 gC affects host-pathogen dynamics in pathways related to immune suppression and infection propagation. The interaction with complement pathways demonstrates its role in inhibiting the activation of these critical immune pathways allowing the virus to evade early host immune detection. A related protein in these pathways is glycoprotein B (gB) which assists in fusion. Together these glycoproteins form a concerted mechanism that ensures effective viral entry and evasion of host defenses highlighting the importance of HSV2 gC in maintaining viral survival.