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AB96431

Anti-HSV2 ICP4 antibody

4

(1 Review)

|

(3 Publications)

Rabbit Polyclonal Varicella Zoster Virus IE62 antibody. Suitable for ELISA, WB and reacts with Recombinant fragment - Human herpesvirus 2 samples. Cited in 3 publications.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

WB, ELISA

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Human herpesvirus 2": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purity is >90%
Storage buffer
pH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HSV2 ICP4 also known as Infected Cell Polypeptide 4 is a significant transcriptional regulator in Herpes Simplex Virus type 2. It works as a major transcription factor necessary for virus replication. ICP4 weighs approximately 160 kDa. It expresses abundantly in cells infected by HSV2 leading to changes in cell function necessary for viral replication. ICP4 binds to DNA in a sequence-specific manner and activates transcription of most viral genes.
Biological function summary

ICP4 is essential to switch on the expression of viral genes during the lytic phase. It is not part of a complex but acts by binding directly to the viral DNA. The protein's function influences the viral lifecycle driving progression into the productive phase. By regulating gene expression ICP4 ensures viral proteins are synthesized in a timely manner during infection.

Pathways

ICP4 plays an instrumental role in the transcriptional activation of HSV2’s gene expression cascade. This pathway includes the viral immediate early (IE) early (E) and late (L) genes ensuring cycle progression. Besides ICP4 regulates interactions with other viral proteins like ICP0 and ICP27 which help maintain efficient replication and transcription processes in infected cells.

ICP4 is closely associated with conditions caused by HSV2 such as genital herpes and its complications. Its constant activity in viral gene regulation makes it a potential target for therapeutic interventions aimed at controlling infection. ICP4’s interplay with ICP0 is critical in viral reactivation contributing to the pathology of recurrent infections.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information HSV2 ICP4
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed35055133

2022

The Peptide A-3302-B Isolated from a Marine Bacterium sp. Inhibits HSV-2 Infection by Preventing the Viral Egress from Host Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sanya Sureram,Irene Arduino,Reiko Ueoka,Massimo Rittà,Rachele Francese,Rattanaporn Srivibool,Dhanushka Darshana,Jörn Piel,Somsak Ruchirawat,Luisa Muratori,David Lembo,Prasat Kittakoop,Manuela Donalisio

Frontiers in immunology 9:2932 PubMed30619292

2018

Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4 T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4.

Applications

Unspecified application

Species

Unspecified reactive species

Mudan Zhang,Xu Deng,Xinmeng Guan,Lanlan Geng,Ming Fu,Binman Zhang,Rui Chen,Huimin Hu,Kai Hu,Di Zhang,Mei Li,Yalan Liu,Sitang Gong,Qinxue Hu

Toxicology and applied pharmacology 289:58-69 PubMed26348139

2015

A fetal whole ovarian culture model for the evaluation of CrVI-induced developmental toxicity during germ cell nest breakdown.

Applications

Unspecified application

Species

Unspecified reactive species

Jone A Stanley,Joe A Arosh,Robert C Burghardt,Sakhila K Banu
View all publications
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Product promise

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