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AB96432

Anti-HSV2 ICP4 antibody

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(1 Publication)

Rabbit Polyclonal Varicella Zoster Virus IE62 antibody. Suitable for ELISA, WB and reacts with Recombinant fragment - Human herpesvirus 2 samples. Cited in 1 publication.

View Alternative Names

Alpha 4 protein, IE175, Infected cell protein 4, Trans acting transcriptional protein ICP4, Transcriptional activator IE175, Transcriptional regulator ICP4

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

ELISA, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Human herpesvirus 2": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purity >90%
Storage buffer
pH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HSV2 ICP4 also known as Infected Cell Polypeptide 4 is a significant transcriptional regulator in Herpes Simplex Virus type 2. It works as a major transcription factor necessary for virus replication. ICP4 weighs approximately 160 kDa. It expresses abundantly in cells infected by HSV2 leading to changes in cell function necessary for viral replication. ICP4 binds to DNA in a sequence-specific manner and activates transcription of most viral genes.
Biological function summary

ICP4 is essential to switch on the expression of viral genes during the lytic phase. It is not part of a complex but acts by binding directly to the viral DNA. The protein's function influences the viral lifecycle driving progression into the productive phase. By regulating gene expression ICP4 ensures viral proteins are synthesized in a timely manner during infection.

Pathways

ICP4 plays an instrumental role in the transcriptional activation of HSV2’s gene expression cascade. This pathway includes the viral immediate early (IE) early (E) and late (L) genes ensuring cycle progression. Besides ICP4 regulates interactions with other viral proteins like ICP0 and ICP27 which help maintain efficient replication and transcription processes in infected cells.

ICP4 is closely associated with conditions caused by HSV2 such as genital herpes and its complications. Its constant activity in viral gene regulation makes it a potential target for therapeutic interventions aimed at controlling infection. ICP4’s interplay with ICP0 is critical in viral reactivation contributing to the pathology of recurrent infections.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information HSV2 ICP4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BMC infectious diseases 20:832 PubMed33176697

2020

Antiviral mechanism of carvacrol on HSV-2 infectivity through inhibition of RIP3-mediated programmed cell necrosis pathway and ubiquitin-proteasome system in BSC-1 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Li Wang,Dan Wang,Xingan Wu,Rui Xu,Yunlan Li
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB96431

Anti-HSV2 ICP4 antibody

primary-antibodies

hsv2-icp4-antibody-ab96431

4

(1 reviews)

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