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AB199148

Anti-HTR3C antibody

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(2 Publications)

Rabbit Polyclonal HTR3C antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human 5-hydroxytryptamine receptor 3C.

View Alternative Names

5-hydroxytryptamine receptor 3C, 5-HT3-C, 5-HT3C, Serotonin receptor 3C, HTR3C

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HTR3C antibody (AB199148)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HTR3C antibody (AB199148)

Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue labeling HTR3C with ab199148 at 1/30 dilution.

Western blot - Anti-HTR3C antibody (AB199148)
  • WB

Supplier Data

Western blot - Anti-HTR3C antibody (AB199148)

8% SDS-PAGE.

All lanes:

Western blot - Anti-HTR3C antibody (ab199148) at 1/500 dilution

All lanes:

HT29 cell lysate at 40 µg

Predicted band size: 50 kDa

true

Exposure time: 20s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human 5-hydroxytryptamine receptor 3C. The exact immunogen used to generate this antibody is proprietary information.

Q8WXA8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HTR3C also known as the 5-HT3C receptor is a subunit of the serotonin receptor family with a mass of approximately 57 kDa. This protein functions as a ligand-gated ion channel facilitating the flow of ions in response to the binding of serotonin. HTR3C is expressed mainly in the central and peripheral nervous system notably found in the brain intestine and various peripheral tissues. It plays a role in modulating neuronal activity by mediating excitatory neurotransmission.
Biological function summary

The serotonin receptor HTR3C influences neuronal communication as part of a complex receptor system. It contributes to the regulation of neurotransmitter release impacting processes like mood anxiety and gut motility. HTR3C forms heteromeric complexes with other 5-HT3 receptor subunits such as HTR3A and HTR3B which alter its functional characteristics. These complexes enhance the specificity and diversity of the serotonergic signaling adapting responses to various physiological demands.

Pathways

Serotonin receptor-related signaling incorporates HTR3C into critical neural and gastrointestinal pathways. The receptor plays an integral role in the nervous system's neurotransmission pathways affecting the balance of excitatory and inhibitory signals. It interacts with proteins involved in the serotonergic system and can couple with intracellular pathways like cAMP signaling to influence cellular responses. HTR3C supports the modulation of pathways by interacting with proteins like PKA involved in neurotransmitter release and neuroplasticity.

HTR3C carries significance in conditions related to neural and gastrointestinal functioning. Dysregulation of this receptor has associations with anxiety disorders and irritable bowel syndrome (IBS). Altered HTR3C activity may impact the body's response to stress and gut motility linking it to these conditions. In these disorders HTR3C interacts with proteins such as SERT the serotonin transporter which influences serotonin availability and receptor activation further complicating pathophysiological outcomes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
See full target information 5-hydroxytryptamine receptor 3C
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

JOR spine 7:e70029 PubMed39717383

2024

CD24 Positive Nucleus Pulposus Cells in Adult Human Intervertebral Discs Maintain a More Notochordal Phenotype Than GD2 Positive Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Andra-Maria Ionescu,Pauline Baird,Sonal Patel,Gareth Howell,Judith A Hoyland,Stephen M Richardson

Journal of oncology 2021:1901191 PubMed34868311

2021

Potential Clinical Value of 5-Hydroxytryptamine Receptor 3C as a Prognostic Biomarker for Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jiun-Rung Chen,Ming-Shyan Huang,Yi-Chen Lee,Min-His Lin,Yi-Fang Yang
View all publications
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Product promise

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