Anti-HTR3C antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

HTR3C also known as the 5-HT3C receptor is a subunit of the serotonin receptor family with a mass of approximately 57 kDa. This protein functions as a ligand-gated ion channel facilitating the flow of ions in response to the binding of serotonin. HTR3C is expressed mainly in the central and peripheral nervous system notably found in the brain intestine and various peripheral tissues. It plays a role in modulating neuronal activity by mediating excitatory neurotransmission.

Biological function summary

The serotonin receptor HTR3C influences neuronal communication as part of a complex receptor system. It contributes to the regulation of neurotransmitter release impacting processes like mood anxiety and gut motility. HTR3C forms heteromeric complexes with other 5-HT3 receptor subunits such as HTR3A and HTR3B which alter its functional characteristics. These complexes enhance the specificity and diversity of the serotonergic signaling adapting responses to various physiological demands.

Pathways

Serotonin receptor-related signaling incorporates HTR3C into critical neural and gastrointestinal pathways. The receptor plays an integral role in the nervous system's neurotransmission pathways affecting the balance of excitatory and inhibitory signals. It interacts with proteins involved in the serotonergic system and can couple with intracellular pathways like cAMP signaling to influence cellular responses. HTR3C supports the modulation of pathways by interacting with proteins like PKA involved in neurotransmitter release and neuroplasticity.

Associated diseases and disorders

HTR3C carries significance in conditions related to neural and gastrointestinal functioning. Dysregulation of this receptor has associations with anxiety disorders and irritable bowel syndrome (IBS). Altered HTR3C activity may impact the body's response to stress and gut motility linking it to these conditions. In these disorders HTR3C interacts with proteins such as SERT the serotonin transporter which influences serotonin availability and receptor activation further complicating pathophysiological outcomes.