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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Recombinant Monoclonal IGHA1 antibody. Suitable for ELISA, sELISA and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Full Length Protein corresponding to Human Immunoglobulin heavy constant alpha 1.
IgG
Rabbit
Preservative: 0.09% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 48% PBS, 1% BSA
Liquid
Monoclonal
ELISA | sELISA | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info - | Notes - |
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
Immunoglobulin heavy constant alpha 1, Ig alpha-1 chain C region, Ig alpha-1 chain C region BUR, Ig alpha-1 chain C region TRO, IGHA1
Rabbit Recombinant Monoclonal IGHA1 antibody. Suitable for ELISA, sELISA and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Full Length Protein corresponding to Human Immunoglobulin heavy constant alpha 1.
Immunoglobulin heavy constant alpha 1, Ig alpha-1 chain C region, Ig alpha-1 chain C region BUR, Ig alpha-1 chain C region TRO, IGHA1
IgG
Rabbit
Preservative: 0.09% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 48% PBS, 1% BSA
Liquid
Monoclonal
RM124
Affinity purification Protein A
Purified from an animal origin–free culture supernatant.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
The antibody contributes to immune defense by binding specifically to antigens. Human IgA1 is part of a larger protein complex within secretory IgA which facilitates immune function at mucosal surfaces. The presence of the secretory component protects IgA1 from degradation by enzymes enhancing the durability of the immune response. Human IgA1 cooperates with other immune system components to prevent pathogen colonization and manage local immune reactions.
Human IgA1 also known as Immunoglobulin A1 plays an important role in the immune response as an antibody. With an approximate mass of 160 kDa it is primarily found in mucous membranes including saliva tears and the respiratory and gastrointestinal tracts. Human IgA1 exists as a monomer in serum but can be dimeric in secretions connected via the J chain and secretory component. It functions to neutralize pathogens and toxins preventing their entry into the body's deeper tissues.
Human IgA1 is involved in the mucosal immune system and the adaptive immune response. These pathways ensure that IgA1 effectively deals with pathogens encountered in mucosal membranes. Its activity is related closely to proteins such as Immunoglobulin J chain which assists in the formation of the dimeric structure and polymeric immunoglobulin receptor which mediates its transcytosis to secretions. These interactions illustrate its central role in pathway transactions that protect mucosal health.
Human IgA1 has associations with IgA nephropathy and celiac disease. In IgA nephropathy aberrant glycosylation of IgA1 leads to mesangial deposition in kidneys triggering inflammation. The process links to proteins like galactose-deficient IgA1 playing a role in disease progression. In celiac disease the immune response involving IgA1 targets transglutaminase 2 in response to gluten. These links highlight the significance of IgA1 in pathogenesis and progression of these immune-related conditions underlining its importance in disease contexts.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Sandwich ELISA using ab193187 as the capture antibody (100ng/well), and Biotinylated anti-human light chains ( κ+ λ) antibody as the detection antibody, followed by an alkaline phosphatase conjugated streptavidin.
Sandwich ELISA using ab193187 as the capture antibody (100ng/well), and Biotinylated anti-human light chains ( κ+ λ) antibody
as the detection antibody, followed by an alkaline phosphatase conjugated streptavidin.
ELISA of Human immunoglobulins (the plate was coated with 50 ng/well of different immunoglobulins) using ab193187 at 200 ng/mL, 50 ng/mL, or 10 ng/mL as the primary antibody. An alkaline phosphatase conjugated anti-rabbit IgG was used as the secondary antibody. The graph shows ab193187 only reacted to Human IgA. There is very slightly cross reactivity with IgA2. No cross reactivity occurs with Human IgG, IgM, IgD, or IgE.
A titer ELISA of Human IgA1 with ab193187 as the primary antibody. The plate was coated with Human IgA1 at different concentrations then a serial dilution of ab193187 was used as the primary antibody . An alkaline phosphatase conjugated anti-rabbit IgG was used as the secondary antibody.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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