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AB103977

Anti-HYAL1 antibody

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(2 Publications)

Rabbit Polyclonal HYAL1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HYAL1 aa 200 to C-terminus.

View Alternative Names

LUCA1, HYAL1, Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1

1 Images
Western blot - Anti-HYAL1 antibody (AB103977)
  • WB

Unknown

Western blot - Anti-HYAL1 antibody (AB103977)

10% SDS-PAGE.

All lanes:

Western blot - Anti-HYAL1 antibody (ab103977) at 1/1000 dilution

All lanes:

HeLa whole cell lysate at 30 µg

Predicted band size: 48 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human HYAL1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q12794

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Have you thought about this alternative?

AB180143

Anti-HYAL1 antibody [EPR5542]

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We’re constantly upgrading our range to offer the highest quality products. We have selected this alternative product for your review because it gives improved performance, is easier and more convenient to use, or is available faster.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HYAL1 also known as hyaluronidase-1 functions as an enzyme that catalyzes the degradation of hyaluronic acid into smaller oligosaccharides. It possesses a mass of approximately 57 kDa. This enzyme is expressed in various tissues including the liver spleen and kidney. HYAL1 plays an essential role in the turnover of extracellular matrix components impacting tissue remodeling and cell migration.
Biological function summary

Hyaluronidase-1 facilitates the breakdown of hyaluronic acid a major component of the extracellular matrix affecting cellular interactions and signaling pathways. HYAL1 does not operate as part of a protein complex but acts individually. Its enzymatic activity influences processes such as cell proliferation tissue repair and inflammatory response as hyaluronic acid fragments modulate these cellular behaviors.

Pathways

Hyaluronidase-1 engages in significant pathways involved in extracellular matrix organization and degradation. It interacts within the hyaluronan metabolism pathway impacting proteins like CD44 and RHAMM which are involved in cell adhesion and motility. By processing hyaluronic acid HYAL1 affects these pathways influencing cellular dynamics and homeostasis.

Abnormal HYAL1 function associates with conditions such as cancer and osteoarthritis. In cancer increased hyaluronidase-1 activity correlates with tumor progression and metastasis as it promotes cancer cell invasion through the extracellular matrix. In osteoarthritis enzymatic degradation of hyaluronic acid disrupts cartilage integrity exacerbating disease symptoms. Additionally the interaction of hyaluronidase-1 with proteins like CD44 in these conditions may further drive pathological changes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
See full target information HYAL1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 294:11458-11472 PubMed31175155

2019

Hyaluronidase-4 is produced by mast cells and can cleave serglycin chondroitin sulfate chains into lower molecular weight forms.

Applications

Unspecified application

Species

Unspecified reactive species

Brooke L Farrugia,Shuji Mizumoto,Megan S Lord,Robert L O'Grady,Rhiannon P Kuchel,Shuhei Yamada,John M Whitelock

Molecular medicine reports 14:2555-65 PubMed27484148

2016

Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis.

Applications

IHC

Species

Unspecified reactive species

Chao Huang,Hong Liu,Xiuli Gong,Bin Wen,Dan Chen,Jinyuan Liu,Fengliang Hu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB203293

Anti-HYAL1 antibody

primary-antibodies

hyal1-antibody-ab203293

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