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AB126099

Anti-HYAL2 antibody

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(2 Publications)

Rabbit Polyclonal HYAL2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HYAL2 aa 100-350.

View Alternative Names

LUCA2, HYAL2, Hyaluronidase-2, Hyal-2, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2

1 Images
Western blot - Anti-HYAL2 antibody (AB126099)
  • WB

Unknown

Western blot - Anti-HYAL2 antibody (AB126099)

10% SDS Page

All lanes:

Western blot - Anti-HYAL2 antibody (ab126099) at 1/1000 dilution

All lanes:

293T cell lysate at 30 µg

Predicted band size: 54 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human HYAL2 aa 100-350. The exact immunogen used to generate this antibody is proprietary information.

Q12891

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Alternative Products

Primary Antibodies

AB68608

Anti-HYAL2 antibody

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Primary Antibodies

AB90004

Anti-HYAL2 antibody

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Complementary Products

Primary Antibodies

AB290669

Anti-Hyaluronan synthase 2 antibody [EPR24637-109] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-Hyaluronan synthase 2 antibody [EPR24637-109] - BSA and Azide free (Detector) (AB290669)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Proteins & Peptides

AB289782

Recombinant Human HYAL2 protein

SDS-PAGE - Recombinant Human HYAL2 protein (AB289782)

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Primary Antibodies

AB189524

Anti-CD44 antibody [EPR18668]

RabMAb|Recombinant|Lab Essentials|20ul selling size|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD44 antibody [EPR18668] (AB189524)

  • 5
  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Sheep": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HYAL2 also known as hyaluronoglucosaminidase 2 is an enzyme that helps break down hyaluronic acid a large polysaccharide present in the extracellular matrix. With a molecular mass of about 60 kDa HYAL2 plays an important mechanical role in the catabolism of hyaluronic acid by cleaving it into smaller fragments. HYAL2 is mainly expressed in tissue such as heart kidney and spleen exhibiting various physiological functions across different organisms.
Biological function summary

Hyaluronoglucosaminidase 2 contributes to the degradation of hyaluronic acid by acting at the cell surface. It operates as part of a complex with CD44 a cell surface receptor involved in cell adhesion and signaling. This interaction allows HYAL2 to localize hyaluronic acid degradation to the cell membrane which influences cellular responses like migration and proliferation. By controlling the size of hyaluronic acid fragments HYAL2 modulates immune responses and tissue remodeling.

Pathways

Several essential processes involve hyaluronoglucosaminidase 2 including the hyaluronan metabolic pathway and the extracellular matrix remodeling pathways. In the hyaluronan metabolic pathway HYAL2 works alongside related enzymes such as HYAL1 to ensure the breakdown and turnover of hyaluronic acid. The regulated degradation of hyaluronic acid by these enzymes is necessary for proper cellular homeostasis and impacts cellular processes such as wound healing and angiogenesis.

Research links hyaluronoglucosaminidase 2 to conditions like cancer and pulmonary hypertension. It relates to cancer because HYAL2's role in hyaluronic acid catabolism can influence tumor progression and metastasis. For pulmonary hypertension alterations in hyaluronic acid levels can affect vascular architecture and function. Additionally interactions with proteins such as CD44 and HYAL1 suggest potential pathways through which HYAL2 could contribute to these diseases influencing therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
See full target information HYAL2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 12:102 PubMed33473125

2021

Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Zhang,Guoyu Yin,Heping Zhao,Hanzhi Ling,Zhen Xie,Chipeng Xiao,Yan Chen,Yufan Lin,Tao Jiang,Shengwei Jin,Jianguang Wang,Xinyu Yang

The Journal of investigative dermatology 140:455-464.e8 PubMed31344385

2019

LRG1 Promotes Keratinocyte Migration and Wound Repair through Regulation of HIF-1α Stability.

Applications

Unspecified application

Species

Unspecified reactive species

Ya Gao,Zhibo Xie,Chiakang Ho,Jing Wang,Qingfeng Li,Yifan Zhang,Jia Zhou
View all publications
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Product promise

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