Rabbit Polyclonal HYAL2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HYAL2 aa 100-350.
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- Cell death & disease 12:1022021Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWei Zhang et. al.PubMed 33473125
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human HYAL2 aa 100-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q12891
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Cow | Predicted |
| Pig | Predicted |
| Sheep | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Sheep, Cow, Pig | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
Alternative names
Hyaluronidase-2, Hyal-2, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2, HYAL2, LUCA2
Recommended products
Rabbit Polyclonal HYAL2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HYAL2 aa 100-350.
Alternative names
Hyaluronidase-2, Hyal-2, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2, HYAL2, LUCA2
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human HYAL2 aa 100-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q12891
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
HYAL2 also known as hyaluronoglucosaminidase 2 is an enzyme that helps break down hyaluronic acid a large polysaccharide present in the extracellular matrix. With a molecular mass of about 60 kDa HYAL2 plays an important mechanical role in the catabolism of hyaluronic acid by cleaving it into smaller fragments. HYAL2 is mainly expressed in tissue such as heart kidney and spleen exhibiting various physiological functions across different organisms.
- Biological function summary
Hyaluronoglucosaminidase 2 contributes to the degradation of hyaluronic acid by acting at the cell surface. It operates as part of a complex with CD44 a cell surface receptor involved in cell adhesion and signaling. This interaction allows HYAL2 to localize hyaluronic acid degradation to the cell membrane which influences cellular responses like migration and proliferation. By controlling the size of hyaluronic acid fragments HYAL2 modulates immune responses and tissue remodeling.
- Pathways
Several essential processes involve hyaluronoglucosaminidase 2 including the hyaluronan metabolic pathway and the extracellular matrix remodeling pathways. In the hyaluronan metabolic pathway HYAL2 works alongside related enzymes such as HYAL1 to ensure the breakdown and turnover of hyaluronic acid. The regulated degradation of hyaluronic acid by these enzymes is necessary for proper cellular homeostasis and impacts cellular processes such as wound healing and angiogenesis.
- Associated diseases and disorders
Research links hyaluronoglucosaminidase 2 to conditions like cancer and pulmonary hypertension. It relates to cancer because HYAL2's role in hyaluronic acid catabolism can influence tumor progression and metastasis. For pulmonary hypertension alterations in hyaluronic acid levels can affect vascular architecture and function. Additionally interactions with proteins such as CD44 and HYAL1 suggest potential pathways through which HYAL2 could contribute to these diseases influencing therapeutic strategies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-HYAL2 antibody (ab126099)
10% SDS Page
All lanes: Western blot - Anti-HYAL2 antibody (ab126099) at 1/1000 dilution
All lanes: 293T cell lysate at 30 µg
Predicted band size: 54 kDa
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