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AB90004

Anti-HYAL2 antibody

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(2 Publications)

Rabbit Polyclonal HYAL2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human HYAL2.

View Alternative Names

LUCA2, HYAL2, Hyaluronidase-2, Hyal-2, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HYAL2 antibody (AB90004)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HYAL2 antibody (AB90004)

ab90004, at a dilution of 1/100, staining HYAL2 in the membrane of formalin fixed, paraffin embedded Human fetal thymus by Immunohistochemistry.
(A) : No immunizing peptide
(B) : Blocked with immunizing peptide

Western blot - Anti-HYAL2 antibody (AB90004)
  • WB

Unknown

Western blot - Anti-HYAL2 antibody (AB90004)

All lanes:

Western blot - Anti-HYAL2 antibody (ab90004) at 1/500 dilution

All lanes:

SW480 cell lysate

Predicted band size: 54 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human HYAL2. The exact immunogen used to generate this antibody is proprietary information.

Q12891

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Alternative Products

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Complementary Products

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Secondary Antibodies

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Proteins & Peptides

AB289782

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Primary Antibodies

AB189524

Anti-CD44 antibody [EPR18668]

RabMAb|Recombinant|Lab Essentials|20ul selling size|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD44 antibody [EPR18668] (AB189524)

  • 5
  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with water at 200µL
Purification technique
Affinity purification Immunogen
Purification notes
Purified by peptide affinity column
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 2% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HYAL2 also known as hyaluronoglucosaminidase 2 is an enzyme that helps break down hyaluronic acid a large polysaccharide present in the extracellular matrix. With a molecular mass of about 60 kDa HYAL2 plays an important mechanical role in the catabolism of hyaluronic acid by cleaving it into smaller fragments. HYAL2 is mainly expressed in tissue such as heart kidney and spleen exhibiting various physiological functions across different organisms.
Biological function summary

Hyaluronoglucosaminidase 2 contributes to the degradation of hyaluronic acid by acting at the cell surface. It operates as part of a complex with CD44 a cell surface receptor involved in cell adhesion and signaling. This interaction allows HYAL2 to localize hyaluronic acid degradation to the cell membrane which influences cellular responses like migration and proliferation. By controlling the size of hyaluronic acid fragments HYAL2 modulates immune responses and tissue remodeling.

Pathways

Several essential processes involve hyaluronoglucosaminidase 2 including the hyaluronan metabolic pathway and the extracellular matrix remodeling pathways. In the hyaluronan metabolic pathway HYAL2 works alongside related enzymes such as HYAL1 to ensure the breakdown and turnover of hyaluronic acid. The regulated degradation of hyaluronic acid by these enzymes is necessary for proper cellular homeostasis and impacts cellular processes such as wound healing and angiogenesis.

Research links hyaluronoglucosaminidase 2 to conditions like cancer and pulmonary hypertension. It relates to cancer because HYAL2's role in hyaluronic acid catabolism can influence tumor progression and metastasis. For pulmonary hypertension alterations in hyaluronic acid levels can affect vascular architecture and function. Additionally interactions with proteins such as CD44 and HYAL1 suggest potential pathways through which HYAL2 could contribute to these diseases influencing therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
See full target information HYAL2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 21:1915-1928 PubMed28378397

2017

Relationship among LRP1 expression, Pyk2 phosphorylation and MMP-9 activation in left ventricular remodelling after myocardial infarction.

Applications

Unspecified application

Species

Unspecified reactive species

Elena Revuelta-López,Carol Soler-Botija,Laura Nasarre,Aleyda Benitez-Amaro,David de Gonzalo-Calvo,Antoni Bayes-Genis,Vicenta Llorente-Cortés

Reproduction, fertility, and development 28:936-947 PubMed25562384

2015

Histochemical structure and immunolocalisation of the hyaluronan system in the dromedary oviduct.

Applications

Unspecified application

Species

Unspecified reactive species

Omnia Mohey-Elsaeed,Waleed F A Marei,Ali A Fouladi-Nashta,Abdel-Aleem A El-Saba
View all publications
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Product promise

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