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AB232785

Anti-ICAM5 antibody

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(2 Publications)

Rabbit Polyclonal ICAM5 antibody. Suitable for WB, IHC-P and reacts with Mouse, Pig, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ICAM5 aa 400-700.

View Alternative Names

TLCN, TLN, ICAM5, Intercellular adhesion molecule 5, ICAM-5, Telencephalin

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ICAM5 antibody (AB232785)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ICAM5 antibody (AB232785)

Formalin-fixed, paraffin-embedded human brain tissue stained for ICAM5 with ab232785 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-ICAM5 antibody (AB232785)
  • WB

Supplier Data

Western blot - Anti-ICAM5 antibody (AB232785)

All lanes:

Western blot - Anti-ICAM5 antibody (ab232785) at 2 µg/mL

All lanes:

Recombinant human ICAM5 protein

Predicted band size: 97 kDa

false

Western blot - Anti-ICAM5 antibody (AB232785)
  • WB

Supplier Data

Western blot - Anti-ICAM5 antibody (AB232785)

All lanes:

Western blot - Anti-ICAM5 antibody (ab232785) at 1 µg/mL

All lanes:

Mouse cerebrum lysate

Predicted band size: 97 kDa

false

Western blot - Anti-ICAM5 antibody (AB232785)
  • WB

Supplier Data

Western blot - Anti-ICAM5 antibody (AB232785)

All lanes:

Western blot - Anti-ICAM5 antibody (ab232785) at 1 µg/mL

All lanes:

Pig cerebrum lysate

Predicted band size: 97 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human, Pig

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human ICAM5 aa 400-700. The exact immunogen used to generate this antibody is proprietary information.

Q9UMF0

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Alternative Products

Primary Antibodies

AB192415

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Complementary Products

Assay Kits

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Human ICAM5 ELISA Kit

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Sandwich ELISA - Human ICAM5 ELISA Kit (AB314854)

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Secondary Antibodies

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Primary Antibodies

AB15580

Anti-Ki67 antibody

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Proteins & Peptides

AB276709

Recombinant Human ICAM5 protein (His tag)

SDS-PAGE - Recombinant Human ICAM5 protein (His tag) (AB276709)

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  • 0
Primary Antibodies

AB7817

Anti-alpha smooth muscle Actin antibody [1A4]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [1A4] (AB7817)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ICAM5 also known as Telencephalin is an intercellular adhesion molecule with a molecular mass of approximately 130 kDa. This protein is mainly expressed in the brain specifically in neurons of the telencephalon region. ICAM5 belongs to the immunoglobulin superfamily and plays a role in cell-cell adhesion. It does not demonstrate tight adherence like other ICAMs which suggests its specific function might differ from other ICAM family members.
Biological function summary

ICAM5 participates in neuron-neuron adhesion processes. It plays a significant role in the development and maintenance of synaptic structures in the nervous system. ICAM5 does not form a complex with other proteins in its functioning. It contributes to the organization and stabilization of dendritic spines which are important for synaptic plasticity and neural communication. This involvement highlights the importance of ICAM5 in neural development and synaptic function.

Pathways

ICAM5 integrates into signaling pathways related to neuronal development and synaptic plasticity. It is a part of the adhesion and cell recognition processes in neural systems. Through its involvement ICAM5 associates with pathways like the glutamatergic synapse pathway. Additionally ICAM5 shows a connection with proteins involved in membrane transport and neuronal signaling such as NMDARs (N-methyl-D-aspartate receptors) emphasizing its role in synaptic modulation.

ICAM5 relates to conditions affecting the nervous system such as schizophrenia and Alzheimer's disease. Studies indicate alterations in ICAM5 expression levels in patients with these diseases suggesting a potential impact on synaptic integrity and function. In Alzheimer's disease ICAM5 interacts with pathways involving beta-amyloid peptide accumulation indicating a possible connection with oxidative stress and neurodegenerative processes. In schizophrenia disruptions in ICAM5 associations with neural adhesion molecules could affect synaptic signaling and stability contributing to cognitive deficits.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL : ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring neuron cell-leukocyte adhesion (PubMed : 8995416). Creates homophilic cell adhesion promoting dendritogenesis and arborization of hippocampal neurons (PubMed : 10893271).
See full target information ICAM5
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 31: PubMed39886972

2025

Triptolide reverses cis‑diamminedichloroplatinum resistance in esophageal squamous cell carcinoma by suppressing glycolysis and causing mitochondrial malfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Kuiyuan Liu,Jia Liu,Tiebao Meng,Nan Wu,Juntao Liu,Mingxu Qiao,Liangyi Dong,Jingeng Liu

The Journal of neuroscience : the official journal of the Society for Neuroscience 40:1355-1365 PubMed31882402

2019

ICAM5 as a Novel Target for Treating Cognitive Impairment in Fragile X Syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Ya-Ping Pei,Yue-Yi Wang,Dan Liu,Hui-Yang Lei,Zhi-Hao Yang,Zi-Wei Zhang,Man Han,Ke Cheng,Yu-Shan Chen,Jin-Quan Li,Gui-Rong Cheng,Lang Xu,Qing-Ming Wu,Shawn M McClintock,Ying Yang,Yong Zhang,Yan Zeng
View all publications
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Product promise

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