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AB171919

Anti-IFI27 antibody

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(9 Publications)

Rabbit Polyclonal IFI27 antibody. Suitable for WB and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IFI27.

View Alternative Names

p27, Interferon alpha-induced 11.5 kDa protein, Interferon-stimulated gene 12a protein, ISG12(a), ISG12A, IFI27

1 Images
Western blot - Anti-IFI27 antibody (AB171919)
  • WB

Supplier Data

Western blot - Anti-IFI27 antibody (AB171919)

All lanes:

Western blot - Anti-IFI27 antibody (ab171919) at 1 µg/mL

Lane 1:

IFI27-transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Rabbit IgG (H+L) at 1/7500 dilution

Predicted band size: 11 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human IFI27.

P40305

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IFI27 also known as Interferon alpha-inducible protein 27 is a small protein with a molecular mass of around 12 kilodaltons. This protein is expressed predominantly in response to type I interferons and some other stimuli. It mainly appears in tissues like the skin and liver which are involved in immune responses. IFI27 localizes to the mitochondria suggesting its role in regulating cellular apoptosis.
Biological function summary

IFI27 plays a significant role in mediating apoptosis the programmed cell death essential for normal cellular turnover and homeostasis. Although it does not typically form part of a larger protein complex its induction by interferons implicates it in antiviral defense mechanisms. Its expression can lead to changes in mitochondrial membrane potential ultimately affecting cell survival.

Pathways

IFI27 participates in important pathways related to immunity and apoptosis. Particularly it engages in the interferon signaling pathway influencing the cellular defense against viral infections. It interacts with other proteins like STAT1 and STAT2 which are key transcription factors in the interferon signaling cascade modulating downstream antiviral responses.

IFI27 has associations with chronic liver diseases and certain autoimmune conditions such as systemic lupus erythematosus (SLE). Its elevated expression often indicates an active immune response or cellular stress. IFI27's expression relates to IFI6 another interferon-inducible protein both of which are implicated in the cellular responses observed in these conditions. Understanding IFI27's role may help in developing therapeutic strategies for targeting immune-related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable adapter protein involved in different biological processes (PubMed : 22427340, PubMed : 27194766). Part of the signaling pathways that lead to apoptosis (PubMed : 18330707, PubMed : 24970806, PubMed : 27673746). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed : 18330707, PubMed : 27673746). Also functions in TNFSF10-induced apoptosis (PubMed : 24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed : 22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed : 27194766, PubMed : 27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed : 27194766, PubMed : 27777077). Also promotes virus-induced pyroptosis by activating CASP3 in the mitochondria after 'Lys-6'-linked ubiquitination by TRIM21 (PubMed : 36426955).
See full target information IFI27
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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Thoracic cancer 16:e70013 PubMed39993992

2025

HOXA5 Derives the Malignant Progression and Cisplatin Resistance of Esophageal Squamous Cell Carcinoma by Regulating USP18-Mediated IFI27 Deubiquitination.

Applications

Unspecified application

Species

Unspecified reactive species

Qiang Wang,Shiheng Ren,Zheng Pan,Yuxin Chen,Xiangyan Liu

Scientific reports 14:24002 PubMed39402115

2024

Altered expression pattern of immune response-related genes and isoforms in hypersensitivity pneumonitis lung fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Ana Lilia Torres-Machorro,Carina Becerril,Everardo Hernández-Plata,Erika Rubí Luis-García,Mariel Maldonado,Iliana Herrera,Miguel Negreros,Fernando Hernández-Sánchez,Criselda Mendoza-Milla,Miguel Gaxiola,Remedios Ramírez,Annie Pardo,Ivette Buendía-Roldán,Moisés Selman,José Cisneros

iScience 27:110127 PubMed38966571

2024

Single-cell sequencing of immune cells from the coronary sinus reveals immune mechanisms of the progression of persistent atrial fibrillation.

Applications

Unspecified application

Species

Unspecified reactive species

Chaofeng Chen,Yang Pang,Kuan Cheng,Xiaofei Gao,Yunlong Ling,Ye Xu,Jing Wu,Yi-Zhou Xu,Qingxing Chen,Wen-Qing Zhu,Jun-Bo Ge

Cells 12: PubMed37508582

2023

Evolving Acquired Vemurafenib Resistance in a BRAF V600E Mutant Melanoma PDTX Model to Reveal New Potential Targets.

Applications

Unspecified application

Species

Unspecified reactive species

József Tóvári,Diána Vári-Mező,Sára Eszter Surguta,Andrea Ladányi,Attila Kigyós,Mihály Cserepes

Journal of medical virology 95:e28706 PubMed36971141

2023

Integrative bulk and single-cell transcriptome profiling analysis reveals IFI27 as a novel interferon-stimulated gene in dengue.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng Jiang,Cong He,Jing Kan,Huiting Guan,Tao Zhou,Yi Yang

American journal of translational research 13:1037-1050 PubMed33841638

2021

lncRNA SNHG17 promotes pancreatic carcinoma progression via cross-talking with miR-942.

Applications

Unspecified application

Species

Unspecified reactive species

Liangchao Zhao,Jinhua Ye,Yifan Lu,Changjie Sun,Xiaxing Deng

Cancer biomarkers : section A of Disease markers 22:453-466 PubMed29758929

2018

miR-370 regulates ISG15 expression and influences IFN-α sensitivity in hepatocellular carcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Zhuo Liu,Min Ma,Lei Yan,Shilin Chen,Sha Li,Darong Yang,Xiaohong Wang,Hua Xiao,Hongyu Deng,Haizhen Zhu,Chaohui Zuo,Man Xia

eLife 5: PubMed27472900

2016

Trisomy 21 consistently activates the interferon response.

Applications

Unspecified application

Species

Unspecified reactive species

Kelly D Sullivan,Hannah C Lewis,Amanda A Hill,Ahwan Pandey,Leisa P Jackson,Joseph M Cabral,Keith P Smith,L Alexander Liggett,Eliana B Gomez,Matthew D Galbraith,James DeGregori,Joaquín M Espinosa

Oncotarget 5:4959-71 PubMed24970806

2014

miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT.

Applications

Unspecified application

Species

Unspecified reactive species

Nianli Liu,Chaohui Zuo,Xiaohong Wang,Tianran Chen,Darong Yang,Jing Wang,Haizhen Zhu
View all publications
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