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AB236657

Anti-IFI44 antibody

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(2 Publications)

Rabbit Polyclonal IFI44 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human IFI44 aa 100-300.

View Alternative Names

MTAP44, IFI44, Interferon-induced protein 44, p44, Microtubule-associated protein 44

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFI44 antibody (AB236657)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFI44 antibody (AB236657)

Paraffin-embedded human kidney tissue stained for IFI44 using ab236657 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-IFI44 antibody (AB236657)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-IFI44 antibody (AB236657)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for IFI44 (green) using ab236657 at 1/100 dilution in ICC/IF. Seconsary antibody was Alexa Fluor 488-conjugated goat anti-rabbit IgG (H+L).

Western blot - Anti-IFI44 antibody (AB236657)
  • WB

Supplier Data

Western blot - Anti-IFI44 antibody (AB236657)

All lanes:

Western blot - Anti-IFI44 antibody (ab236657) at 1/500 dilution

All lanes:

Mouse lung lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 50 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human IFI44 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.

Q8TCB0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IFI44 also known as Interferon-Induced Protein 44 is a protein encoded by the IFI44 gene. This protein has a molecular mass of approximately 49 kDa. IFI44 expresses in various tissues with elevated levels observed in immune-related cells such as leukocytes. Mechanically IFI44 is known to play a role in the antiviral defense mechanisms of cells often upregulated in response to interferon stimuli. It interacts with cytoskeleton elements to mediate its cellular functions.
Biological function summary

IFI44 participates in cellular defense against viral infections by enhancing the immune response. This protein does not function independently but forms part of interferon-stimulated gene complex working together with other proteins to combat virus replication. By regulating this complex IFI44 influences cell signaling and modulates antiviral pathways contributing to the suppression of viral propagation within host cells.

Pathways

IFI44 functions prominently within the interferon signaling pathway and the innate immune response pathway. It collaborates closely with other interferon-stimulated proteins such as ISG15 and MX1 which are engaged in the virus suppression. This cooperation helps orchestrate a swift immune response to external pathogenic threats by inhibiting viral gene expression and replication processes.

IFI44 plays an important role in conditions associated with viral infections such as Hepatitis C and influenza. The protein's interaction with viral defense proteins like ISG15 is significant in these disorders. Its expression levels often correlate with the severity of the disease serving as a biomarker for the infection state. Understanding IFI44's precise role in these diseases could lead to novel therapeutic approaches and better management of viral infections.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

This protein aggregates to form microtubular structures.
See full target information IFI44
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

iMeta 3:e221 PubMed39135698

2024

Cell-type-specific expression analysis of liver transcriptomics with clinical parameters to decipher the cause of intrahepatic inflammation in chronic hepatitis B.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Wang,Qian Li,Yuanwang Qiu,Simo Kitanovski,Chen Wang,Chenxia Zhang,Fahong Li,Xiaoguang Li,Zhenfeng Zhang,Lihua Huang,Jiming Zhang,Daniel Hoffmann,Mengji Lu,Hongzhou Lu

Aging 12: PubMed33493134

2021

Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Pengfei Zhu,Ruo Feng,Xu Lu,Yuan Liao,Zhicheng Du,Wenlong Zhai,Kunlun Chen
View all publications
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