Anti-IFI44 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

IFI44 also known as Interferon-Induced Protein 44 is a protein encoded by the IFI44 gene. This protein has a molecular mass of approximately 49 kDa. IFI44 expresses in various tissues with elevated levels observed in immune-related cells such as leukocytes. Mechanically IFI44 is known to play a role in the antiviral defense mechanisms of cells often upregulated in response to interferon stimuli. It interacts with cytoskeleton elements to mediate its cellular functions.

Biological function summary

IFI44 participates in cellular defense against viral infections by enhancing the immune response. This protein does not function independently but forms part of interferon-stimulated gene complex working together with other proteins to combat virus replication. By regulating this complex IFI44 influences cell signaling and modulates antiviral pathways contributing to the suppression of viral propagation within host cells.

Pathways

IFI44 functions prominently within the interferon signaling pathway and the innate immune response pathway. It collaborates closely with other interferon-stimulated proteins such as ISG15 and MX1 which are engaged in the virus suppression. This cooperation helps orchestrate a swift immune response to external pathogenic threats by inhibiting viral gene expression and replication processes.

Associated diseases and disorders

IFI44 plays an important role in conditions associated with viral infections such as Hepatitis C and influenza. The protein’s interaction with viral defense proteins like ISG15 is significant in these disorders. Its expression levels often correlate with the severity of the disease serving as a biomarker for the infection state. Understanding IFI44’s precise role in these diseases could lead to novel therapeutic approaches and better management of viral infections.