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AB95989

Anti-IFIT3/P60 antibody

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(4 Publications)

Rabbit Polyclonal IFIT3/P60 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human IFIT3 aa 200 to C-terminus.

View Alternative Names

CIG-49, IFI60, IFIT4, ISG60, IFIT3, Interferon-induced protein with tetratricopeptide repeats 3, IFIT-3, CIG49, ISG-60, Interferon-induced 60 kDa protein, Interferon-induced protein with tetratricopeptide repeats 4, Retinoic acid-induced gene G protein, IFI-60K, IFIT-4, P60, RIG-G

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human IFIT3 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O14879

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Alternative Products

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AB118045

Anti-IFIT3/P60 antibody [OTI1G1]

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Primary Antibodies

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Anti-IFIT3/P60 antibody - C-terminal

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Primary Antibodies

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Primary Antibodies

AB236243

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Primary Antibodies

AB285367

Anti-ISG15 antibody [EPR24482-49]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IFIT3 also known as P60 is a member of the IFIT (Interferon-Induced Proteins with Tetratricopeptide Repeats) family of proteins. With a molecular mass of approximately 60 kDa IFIT3 is part of the antiviral response system. This protein is expressed in various tissues and is highly inducible by type I interferons. It functions to inhibit viral replication by interacting with viral RNA. The structure of IFIT3 includes tetratricopeptide repeat motifs which facilitate its role in protein-protein interactions.
Biological function summary

IFIT3 plays a major role in the immune response against viral infections. The protein forms complexes with other IFIT family members like IFIT1 and IFIT2 to enhance antiviral efficacy. IFIT3 binds to foreign RNA lacking proper cap structures blocking viral protein synthesis. The protein's actions help strengthen the innate immune system and further control the spread of viral pathogens. IFIT3 also modulates cellular functions by engaging with signaling pathways that regulate inflammation and immune defense.

Pathways

IFIT3 integrates into important signaling networks such as the interferon-mediated signal transduction pathway and the JAK-STAT signaling pathway. In these pathways IFIT3 along with related proteins like IRF3 and ISG15 helps amplify immune responses after detecting viral threats. Its involvement in these pathways ensures that antiviral states within cells are quickly established reducing viral survival and dissemination.

IFIT3 has significant implications for infection and cancer outcomes. In viral infections such as hepatitis C IFIT3 expression levels correlate with effective antiviral activity and prognosis. In cancer aberrant IFIT3 expression can influence tumorigenesis and impact treatment responses. Collaborating with proteins such as STAT1 and p53 IFIT3 can affect pathways involved in cell proliferation and apoptosis linking immune responses to cancer progression and therapy resistance.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
See full target information IFIT3
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular life sciences : CMLS 82:233 PubMed40512405

2025

The puzzling regulation of the interferon signaling system by the p53 tumor suppressor protein.

Applications

Unspecified application

Species

Unspecified reactive species

Agnieszka Będzińska,Barbara Łasut-Szyszka,Małgorzata Krześniak,Agnieszka Gdowicz-Kłosok,Marek Rusin

International journal of molecular sciences 22: PubMed34681730

2021

Transcriptome Analysis of Cells Exposed to Actinomycin D and Nutlin-3a Reveals New Candidate p53-Target Genes and Indicates That CHIR-98014 Is an Important Inhibitor of p53 Activity.

Applications

Unspecified application

Species

Unspecified reactive species

Barbara Łasut-Szyszka,Beata Małachowska,Agnieszka Gdowicz-Kłosok,Małgorzata Krześniak,Magdalena Głowala-Kosińska,Artur Zajkowicz,Marek Rusin

Molecular cell 81:426-441.e8 PubMed33545059

2021

Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication.

Applications

Unspecified application

Species

Unspecified reactive species

Mathew J K Jones,Camille Gelot,Stephanie Munk,Amnon Koren,Yoshitaka Kawasoe,Kelly A George,Ruth E Santos,Jesper V Olsen,Steven A McCarroll,Mark G Frattini,Tatsuro S Takahashi,Prasad V Jallepalli

Cellular signalling 69:109552 PubMed32032660

2020

Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Małgorzata Krześniak,Artur Zajkowicz,Agnieszka Gdowicz-Kłosok,Magdalena Głowala-Kosińska,Barbara Łasut-Szyszka,Marek Rusin
View all publications
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Product promise

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