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AB167272

Anti-IFIT5 antibody

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(1 Publication)

Mouse Polyclonal IFIT5 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IFIT5.

View Alternative Names

ISG58, RI58, IFIT5, Interferon-induced protein with tetratricopeptide repeats 5, IFIT-5, Interferon-induced 58 kDa protein, Retinoic acid- and interferon-inducible 58 kDa protein, P58

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human IFIT5.

Q13325

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Alternative Products

Primary Antibodies

AB220954

Anti-IFIT5 antibody

Immunocytochemistry/ Immunofluorescence - Anti-IFIT5 antibody (AB220954)

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Primary Antibodies

AB113485

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Complementary Products

Primary Antibodies

AB305301

Anti-IFIT1 antibody [EPR27276-63]

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Primary Antibodies

AB238675

Anti-Interferon beta antibody [C5]

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Primary Antibodies

AB118045

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Primary Antibodies

AB272492

Anti-OAS1 antibody [EPR24824-162]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IFIT5 also known as Interferon-induced protein with tetratricopeptide repeats 5 is a protein with a molecular mass of approximately 56 kDa. This protein is expressed mainly in the cytoplasm where it functions by specifically binding to single-stranded RNAs lacking 2'-O-methylation at their 5'-cap structure. This recognition allows IFIT5 to distinguish self from non-self RNA an important element in immune defense mechanisms. Its ability to sense and bind to viral RNA makes it an important player in the host's innate immune response.
Biological function summary

IFIT5 is involved in antiviral defense and immune response regulation. It does not function as part of a multi-protein complex but interacts with various signaling molecules to amplify immune responses. By selectively binding to foreign RNA IFIT5 can inhibit viral replication and modulate type I interferon signaling pathways. It plays a significant role in restricting viral protein synthesis giving the host organism time to mount an adaptive immune response.

Pathways

IFIT5 is closely associated with the interferon signaling pathway and the innate immune response pathway. Through its interactions it affects the Jak-STAT signaling pathway which is important for the induction of antiviral states in cells. IFIT5 also has functional links with other proteins such as RIG-I an important sensor in the detection of viral RNAs. Together they provide a robust early immune defense by facilitating cytokine production and ensuring rapid response to infections.

IFIT5 has been linked to viral infections and certain inflammatory conditions. Its role in antiviral defense connects it to diseases such as hepatitis C where the protein's influence on interferon action can affect viral persistence and patient response to treatment. Additionally IFIT5 interaction with proteins like PKR moves it to the context of autoimmune disorders where overactive or dysregulated immune responses can lead to chronic inflammation and tissue damage.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed : 23317505, PubMed : 23774268, PubMed : 25092312). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed : 23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed : 23774268). Additionally, as a mediator in innate immunity, positively regulates IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed : 26334375).
See full target information IFIT5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical endocrinology and metabolism 110:693-705 PubMed39183149

2024

BRAF-induced EHF Expression Affects TERT in Aggressive Papillary Thyroid Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yiyi Xu,Jiwei Gao,Na Wang,Jan Zedenius,Inga-Lena Nilsson,Weng-Onn Lui,Dawei Xu,C Christofer Juhlin,Catharina Larsson,Ninni Mu
View all publications
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Product promise

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