Anti-IFITM5 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The IFITM5 protein also known by the name BRIL (Bone Restricted Ifitm-Like) is a membrane protein involved in bone development. It has a molecular mass of approximately 16 kDa. Researchers find it primarily expressed in osteoblasts where it plays a role in forming the mineralized matrix. IFITM5 contains two transmembrane domains which allows it to anchor within the smooth endoplasmic reticulum and exert its functions critical to bone health.

Biological function summary

IFITM5 plays an important role in osteoblast differentiation and bone mineralization. It forms part of a cellular framework required for effective bone formation. Through its activity IFITM5 influences deposition and organization of calcium and phosphate two key components for strong bones. As it works within osteoblasts this protein helps regulate processes that ensure proper bone density and structural integrity.

Pathways

IFITM5 interacts within signaling routes that are integral to osteogenesis. It ties in with the Wnt signaling pathway which is essential for bone homeostasis and osteoblast function. Additionally IFITM5 has associations with the LRP5/6 receptor another component in bone regulation pathways. Through these interactions IFITM5 helps modulate signaling events that determine bone growth and turnover.

Associated diseases and disorders

IFITM5 is closely linked to osteogenesis imperfecta type V a genetic bone disorder characterized by fragile bones prone to fractures. Mutations in the IFITM5 gene result in abnormal bone matrix formation leading to structural deficits. Researchers also study its connection to the COL1A1 and COL1A2 proteins as these proteins share involvement in bone matrix formation and may influence the severity and characteristics of bone disorders.