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AB230863

Anti-IFITM5 antibody

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(3 Publications)

Rabbit Polyclonal IFITM5 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human IFITM5 aa 50-100 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Interferon-induced transmembrane protein 5, Bone-restricted interferon-induced transmembrane protein-like protein, Dispanin subfamily A member 1, BRIL, DSPA1, IFITM5

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFITM5 antibody (AB230863)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFITM5 antibody (AB230863)

Formalin-fixed, paraffin-embedded human placenta tissue stained for IFITM5 using ab230863 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-IFITM5 antibody (AB230863)
  • WB

Supplier Data

Western blot - Anti-IFITM5 antibody (AB230863)

All lanes:

Western blot - Anti-IFITM5 antibody (ab230863) at 1/1000 dilution

All lanes:

Mouse spleen lysate at 35 µg

Predicted band size: 14 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human IFITM5 aa 50-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

A6NNB3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IFITM5 protein also known by the name BRIL (Bone Restricted Ifitm-Like) is a membrane protein involved in bone development. It has a molecular mass of approximately 16 kDa. Researchers find it primarily expressed in osteoblasts where it plays a role in forming the mineralized matrix. IFITM5 contains two transmembrane domains which allows it to anchor within the smooth endoplasmic reticulum and exert its functions critical to bone health.
Biological function summary

IFITM5 plays an important role in osteoblast differentiation and bone mineralization. It forms part of a cellular framework required for effective bone formation. Through its activity IFITM5 influences deposition and organization of calcium and phosphate two key components for strong bones. As it works within osteoblasts this protein helps regulate processes that ensure proper bone density and structural integrity.

Pathways

IFITM5 interacts within signaling routes that are integral to osteogenesis. It ties in with the Wnt signaling pathway which is essential for bone homeostasis and osteoblast function. Additionally IFITM5 has associations with the LRP5/6 receptor another component in bone regulation pathways. Through these interactions IFITM5 helps modulate signaling events that determine bone growth and turnover.

IFITM5 is closely linked to osteogenesis imperfecta type V a genetic bone disorder characterized by fragile bones prone to fractures. Mutations in the IFITM5 gene result in abnormal bone matrix formation leading to structural deficits. Researchers also study its connection to the COL1A1 and COL1A2 proteins as these proteins share involvement in bone matrix formation and may influence the severity and characteristics of bone disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for normal bone mineralization.
See full target information IFITM5
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 134: PubMed38885336

2024

The IFITM5 mutation in osteogenesis imperfecta type V is associated with an ERK/SOX9-dependent osteoprogenitor differentiation defect.

Applications

Unspecified application

Species

Unspecified reactive species

Ronit Marom,I-Wen Song,Emily C Busse,Megan E Washington,Ava S Berrier,Vittoria C Rossi,Laura Ortinau,Youngjae Jeong,Ming-Ming Jiang,Brian C Dawson,Mary Adeyeye,Carolina Leynes,Caressa D Lietman,Bridget M Stroup,Dominyka Batkovskyte,Mahim Jain,Yuqing Chen,Racel Cela,Alexis Castellon,Alyssa A Tran,Isabel Lorenzo,D Nicole Meyers,Shixia Huang,Alicia Turner,Vinitha Shenava,Maegen Wallace,Eric Orwoll,Dongsu Park,Catherine G Ambrose,Sandesh Cs Nagamani,Jason D Heaney,Brendan H Lee

Molecular & cellular proteomics : MCP 21:100273 PubMed35918030

2022

Quantitative Proteomics Identifies Proteins Enriched in Large and Small Extracellular Vesicles.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Lischnig,Markus Bergqvist,Takahiro Ochiya,Cecilia Lässer

Frontiers in immunology 13:827709 PubMed35401540

2022

Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit African Swine Fever Virus Replication.

Applications

Unspecified application

Species

Unspecified reactive species

Siqi Cai,Zezhong Zheng,JiaoJiao Cheng,Lintao Zhong,Ran Shao,Feiyan Zheng,Zhiying Lai,Jiajun Ou,Liang Xu,Pei Zhou,Gang Lu,Guihong Zhang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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