AB171081

Anti-IFN gamma Receptor beta/AF-1 antibody [EPR8813]

RabMAb
Recombinant
What is this?

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(7 Publications)

Rabbit Recombinant Monoclonal IFN gamma Receptor beta/AF-1 antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications.

View Alternative Names

IFNGT1, IFNGR2, Interferon gamma receptor 2, IFN-gamma receptor 2, IFN-gamma-R2, Interferon gamma receptor accessory factor 1, Interferon gamma receptor beta-chain, Interferon gamma transducer 1, AF-1, IFN-gamma-R-beta

1 Images

Supplier Data

Western blot - Anti-IFN gamma Receptor beta/AF-1 antibody [EPR8813] (AB171081)

All lanes:

Western blot - Anti-IFN gamma Receptor beta/AF-1 antibody [EPR8813] (ab171081) at 1/1000 dilution

Lane 1:

Fetal heart tissue lysate at 10 µg

Lane 2:

Human skeletal muscle tissue lysate at 10 µg

Lane 3:

Fetal thymus tissue lysate at 10 µg

Predicted band size: 38 kDa

false

Carrier free

Anti-IFN gamma Receptor beta/AF-1 antibody [EPR8813] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR8813

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: BSA, Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IFN gamma Receptor beta also known as IFN-γ receptor β chain or IFN gamma receptor AF-1 plays a significant role in the immune response. This receptor is part of the interferon gamma receptor complex which binds the cytokine IFN-gamma. The beta chain contributes to the formation of the receptor complex that allows functional IFN-gamma signaling. Typically the receptor is expressed on the surface of immune cells like lymphocytes and macrophages facilitating communication and response to infections and immune challenges. The exact molecular mass can vary depending on glycosylation often giving an approximate mass of 35-50 kDa.

Biological function summary

IFN gamma Receptor beta is essential for the activation of the immune system. It partners with IFN gamma Receptor alpha in the receptor complex to mediate important biological effects such as activation of macrophages and enhancement of antigen presentation. This activity boosts the cellular immune response allowing cells to better combat microbial infections and tumor growth. Without functional receptor activity cells would not effectively respond to IFN-gamma signals impeding proper immune function.

Pathways

IFN gamma Receptor beta is involved in the JAK-STAT signaling pathway which is important for mediating IFN-gamma signaling. Once IFN-gamma binds to its receptor including the beta chain it triggers the activation of JAK kinases which in turn phosphorylates STAT1. Phosphorylated STAT1 dimerizes translocates to the nucleus and influences the expression of immune regulatory genes. This pathway connects the receptor with key immune regulatory proteins playing an important role in the immune response.

IFN gamma Receptor beta is associated with conditions such as chronic granulomatous disease and various mycobacterial infections. These conditions often result from immune system malfunctions where the receptor cannot properly signal IFN-gamma activity leading to an impaired defense against pathogens. The involvement of the receptor in immune pathways links it to other critical proteins like IFN gamma Receptor alpha and STAT1 both of which might be implicated in IFN-gamma-related dysfunctions contributing to these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed : 7615558, PubMed : 7673114, PubMed : 8124716). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed : 15356148, PubMed : 7673114, PubMed : 8124716). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed : 7673114).

See full target information IFNGR2

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 15:1457163 PubMed39575241

2024

The role of S100A8 and S100A9 in external auditory canal cholesteatoma.

Applications

Unspecified application

Species

Unspecified reactive species

Guanwen He,Weijing Han,Zhongshou Zhu,Rifu Wei,Chang Lin

Heliyon 10:e26898 PubMed38439851

2024

Moxibustion alleviates intestinal inflammation in ulcerative colitis rats by modulating long non-coding RNA LOC108352929 and inhibiting Phf11 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Guona Li,Chen Zhao,Jing Xu,Yan Huang,Yu Qiao,Feng Li,Guangbin Peng,Shiyu Zheng,Lu Zhu,Ling Yang,Zhaoqin Wang,Huangan Wu

Cell transplantation 32:9636897231204075 PubMed37798940

2023

Induced Overexpression of B Cell-Activating Factor by Triiodothyronine Results in Abnormal B Cell Differentiation in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Shu Liu,Guo-Qing Li,Qing-Wei Gu,Jie Wang,Qi Sun,Wen-Sha Gu,Xiao-Ming Mao

The Journal of clinical investigation 132: PubMed36066968

2022

BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Guizhen Zhao,Yang Zhao,Haocheng Lu,Ziyi Chang,Hongyu Liu,Huilun Wang,Wenying Liang,Yuhao Liu,Tianqing Zhu,Oren Rom,Yanhong Guo,Lin Chang,Bo Yang,Minerva T Garcia-Barrio,Jiandie D Lin,Y Eugene Chen,Jifeng Zhang

International journal of molecular medicine 47: PubMed33786608

2021

Dexmedetomidine suppresses the development of abdominal aortic aneurysm by downregulating the mircoRNA‑21/PDCD 4 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Yu,Qianqian Li,Xinglong Yang,Qiang Liu,Jun Deng,Yanping Zhao,Ruilin Hu,Min Dai

Aging 12:25229-25255 PubMed33223504

2020

Exposure to ozone impacted Th1/Th2 imbalance of CD T cells and apoptosis of ASMCs underlying asthmatic progression by activating lncRNA PVT1-miR-15a-5p/miR-29c-3p signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yangyang Wei,Baofen Han,Wenjuan Dai,Shufang Guo,Caiping Zhang,Lixuan Zhao,Yan Gao,Yi Jiang,Xiaomei Kong

Cell 175:1336-1351.e17 PubMed30318148

2018

Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoqing Xu,Jia Xu,Jiacheng Wu,Ye Hu,Yanmei Han,Yan Gu,Kai Zhao,Qian Zhang,Xingguang Liu,Juan Liu,Bing Liu,Xuetao Cao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IFN gamma Receptor beta/AF-1 antibody [EPR8813]

Western blot - Anti-IFN gamma Receptor beta/AF-1 antibody [EPR8813] (AB171081)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (7)

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