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AB235515

Anti-IFNA14 antibody

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(1 Publication)

Rabbit Polyclonal IFNA14 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human IFNA14 aa 1 to C-terminus.

View Alternative Names

Interferon alpha-14, IFN-alpha-14, Interferon alpha-H, Interferon lambda-2-H, LeIF H, IFNA14

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFNA14 antibody (AB235515)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFNA14 antibody (AB235515)

Paraffin-embedded human kidney tissue stained for INFA14 using ab235515 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human IFNA14 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P01570

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IFNA14 also known as Interferon Alpha-14 is a low molecular weight protein weighing approximately 19.3 kDa. It belongs to the type I interferon family and functions as a cytokine. IFNA14 is primarily expressed in leukocytes where it exerts its effects on various immune responses. This protein contributes to the antiviral boundaries of cells by binding to specific cell-surface receptors.
Biological function summary

IFNA14 plays an essential role in the immune system response to viral infections. It interacts with the type I interferon receptor complex to activate transcription of interferon-stimulated genes which help to mediate antiviral effects. IFNA14 signals through the JAK-STAT pathway ultimately leading to an increased expression of MHC class I antigens and enhanced immune recognition. Its activity aids in the coordination of the immune system's efforts to combat viral pathogens.

Pathways

IFNA14 is integral to the interferon signaling pathway and plays a part in the innate immune response pathway. These pathways involve a cascade of proteins including JAK1 and STAT2 which mediate its signal transduction. The activation of these pathways leads to transcriptional changes necessary for an effective antiviral state and modulation of the immune response.

IFNA14 has connections with viral infections like Hepatitis C and systemic lupus erythematosus (SLE). Its dysregulation or overexpression can lead to an inappropriate immune response contributing to the pathogenesis of these conditions. The relationship between IFNA14 and other interferon-induced proteins such as IRF7 highlights its significance in disease progression and points to potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes : a protein kinase and an oligoadenylate synthetase.
See full target information IFNA14
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer medicine 12:5035-5054 PubMed36205357

2022

Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance.

Applications

Unspecified application

Species

Unspecified reactive species

Min Tang,Juan Chen,Tian Zeng,Dong-Mei Ye,Yu-Kun Li,Juan Zou,Yu-Ping Zhang
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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