AB232899

Anti-IFNA4 antibody

Name: Anti-IFNA4 antibody (ab232899) | Abcam
Brand: Abcam Limited
SKU: AB232899
Price: 525 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal IFNA4 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human IFNA4 aa 1 to C-terminus.

View Alternative Names

Interferon alpha-4, IFN-alpha-4, Interferon alpha-4B, Interferon alpha-76, Interferon alpha-M1, IFNA4

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFNA4 antibody (AB232899)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFNA4 antibody (AB232899)

Formalin-fixed, paraffin-embedded human liver tissue stained for IFNA4 using ab232899 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFNA4 antibody (AB232899)

Formalin-fixed, paraffin-embedded human brain tissue stained for IFNA4 using ab232899 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-IFNA4 antibody (AB232899)

All lanes:

Western blot - Anti-IFNA4 antibody (ab232899) at 2 µg/mL

All lanes:

Recombinant human IFNA4 protein

Predicted band size: 22 kDa,77 kDa

false

Supplier Data

Western blot - Anti-IFNA4 antibody (AB232899)

All lanes:

Western blot - Anti-IFNA4 antibody (ab232899) at 2 µg/mL

All lanes:

Mouse lymphocyte lysate

Predicted band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human IFNA4 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P05014

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IFNA4 gene encodes a member of the alpha interferon family commonly known as Interferon alpha-4 (IFN-α4). This protein plays an important role in the immune response acting as a signaling molecule that helps regulate the activity of the immune system. IFN-α4 consists of approximately 20 kilodaltons in mass. It is expressed in various tissues but is most abundant in blood cells and at sites of infection or inflammation.

Biological function summary

Interferon alpha-4 engages in antiviral defense mechanisms by binding to specific receptors on the surface of cells triggering a cascade of cellular responses to represent an antiviral state. This state restricts viral replication within host cells. IFN-α4 forms part of a diverse family of cytokines known as type I interferons. These cytokines all share the common mechanism of activating immune responses.

Pathways

The involvement of interferon alpha-4 in the Jak-STAT pathway is significant for transducing signals that lead to the expression of interferon-stimulated genes (ISGs). It closely interacts with other proteins like STAT1 and STAT2 which play important roles in this signaling cascade. By triggering these pathways IFN-α4 and related proteins contribute to the host's defense against infections.

Abnormalities in IFN-α4 expression or function can relate to autoimmune diseases such as Systemic Lupus Erythematosus (SLE) where excessive interferon activity can damage tissues. Chronic Hepatitis C infection is another condition linked to this protein where altered IFN-α responsiveness complicates viral clearance. IFN-α4's interactions with other cytokines such as IFN-β may also influence the disease states and progression.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes : a protein kinase and an oligoadenylate synthetase.

See full target information IFNA4

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of biological sciences 21:1275-1293 PubMed39897035

2025

Exosomal mediated lipid metabolism, ferritinophagy and CoQ-dependent pathway contributes to the ferroptosis of keratinocyte in SJS/TEN.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Zhang,Pei Qiao,ChunYing Xiao,ZiPeng Cao,JiaoLing Chen,Hui Fang,JianKang Yang,ZeHua Kang,ErLe Dang,Shuai Shao,BingYu Pang,QingYang Li,ZhenLai Zhu,ShengXian Shen,Akito Hasegawa,Riichiro Abe,HongJiang Qiao,Gang Wang,Meng Fu

Viruses 15: PubMed36851534

2023

Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Cláudia Calvielli Castelo Branco,Emily Araujo De Oliveira,Nátalli Zanete Pereira,Ricardo Wesley Alberca,Amaro Nunes Duarte-Neto,Luiz Fernando Ferraz Da Silva,Fernanda Guedes Luiz,Naiura Vieira Pereira,Mirian Nacagami Sotto,Naiara Naiana Dejani,Patrícia Helen Carvalho Rondó,Elyzabeth Avvad-Portari,Zilton Farias Meira De Vasconcelos,Alberto José da Silva Duarte,Tamiris Azamor,Maria Notomi Sato

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IFNA4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFNA4 antibody (AB232899)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFNA4 antibody (AB232899)

Western blot - Anti-IFNA4 antibody (AB232899)

Western blot - Anti-IFNA4 antibody (AB232899)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise