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AB230843

Anti-IFNA4 antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal IFNA4 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human IFNA4 aa 150 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Interferon alpha-4, IFN-alpha-4, Interferon alpha-4B, Interferon alpha-76, Interferon alpha-M1, IFNA4

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFNA4 antibody - C-terminal (AB230843)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFNA4 antibody - C-terminal (AB230843)

Formalin-fixed, paraffin-embedded human testis tissue stained for IFNA4 using ab230843 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFNA4 antibody - C-terminal (AB230843)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFNA4 antibody - C-terminal (AB230843)

Formalin-fixed, paraffin-embedded human tonsil tissue stained for IFNA4 using ab230843 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-IFNA4 antibody - C-terminal (AB230843)
  • WB

Supplier Data

Western blot - Anti-IFNA4 antibody - C-terminal (AB230843)

All lanes:

Western blot - Anti-IFNA4 antibody - C-terminal (ab230843) at 1/1000 dilution

All lanes:

U937 (human histiocytic lymphoma cell line) cell lysate at 35 µg

Predicted band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human IFNA4 aa 150 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P05014

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Alternative Products

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IFNA4 gene encodes a member of the alpha interferon family commonly known as Interferon alpha-4 (IFN-α4). This protein plays an important role in the immune response acting as a signaling molecule that helps regulate the activity of the immune system. IFN-α4 consists of approximately 20 kilodaltons in mass. It is expressed in various tissues but is most abundant in blood cells and at sites of infection or inflammation.
Biological function summary

Interferon alpha-4 engages in antiviral defense mechanisms by binding to specific receptors on the surface of cells triggering a cascade of cellular responses to represent an antiviral state. This state restricts viral replication within host cells. IFN-α4 forms part of a diverse family of cytokines known as type I interferons. These cytokines all share the common mechanism of activating immune responses.

Pathways

The involvement of interferon alpha-4 in the Jak-STAT pathway is significant for transducing signals that lead to the expression of interferon-stimulated genes (ISGs). It closely interacts with other proteins like STAT1 and STAT2 which play important roles in this signaling cascade. By triggering these pathways IFN-α4 and related proteins contribute to the host's defense against infections.

Abnormalities in IFN-α4 expression or function can relate to autoimmune diseases such as Systemic Lupus Erythematosus (SLE) where excessive interferon activity can damage tissues. Chronic Hepatitis C infection is another condition linked to this protein where altered IFN-α responsiveness complicates viral clearance. IFN-α4's interactions with other cytokines such as IFN-β may also influence the disease states and progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes : a protein kinase and an oligoadenylate synthetase.
See full target information IFNA4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Foods (Basel, Switzerland) 11: PubMed36010498

2022

Si-Wu Water Extracts Protect against Colonic Mucus Barrier Damage by Regulating Muc2 Mucin Expression in Mice Fed a High-Fat Diet.

Applications

Unspecified application

Species

Unspecified reactive species

Zheng Ruan,Yujuan Yu,Peiheng Han,Li Zhang,Zhongyi Hu
View all publications
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Product promise

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