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AB168119

Anti-IFNK antibody

5

(1 Review)

|

(3 Publications)

Rabbit Polyclonal IFNK antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IFNK.

View Alternative Names

UNQ6124/PRO20084, IFNK, Interferon kappa, IFN-kappa

1 Images
Western blot - Anti-IFNK antibody (AB168119)
  • WB

Unknown

Western blot - Anti-IFNK antibody (AB168119)

All lanes:

Western blot - Anti-IFNK antibody (ab168119) at 1 µg/mL

Lane 1:

IFNK Transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected lysate at 15 µL

Secondary

All lanes:

Goat Anti-Rabbit IgG at 1/7500 dilution

Predicted band size: 25 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human IFNK.

Q9P0W0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IFNK gene encodes for Interferon Kappa a member of the Type I interferon family. Interferon Kappa has a molecular mass of approximately 22 kDa. This protein is mainly expressed in keratinocytes which are the predominant cell type in the epidermis. Interferon Kappa shows expression also in tissues such as the spleen and liver. The protein plays a role in skin immune responses contributing to the regulation of epidermal homeostasis and the first line of defense against viral infections.
Biological function summary

Interferon Kappa initiates antiviral antiproliferative and immunomodulatory activities. Unlike some other interferons it mainly functions within epithelial tissues and has limited expression outside these areas. Interferon Kappa activates certain signal transduction pathways particularly through the JAK-STAT signaling complex. This activation leads to transcription of IFN-stimulated genes that are pivotal for the host antiviral state. Its actions include inhibition of viral replication and modulation of the immune system to enhance pathogen clearance.

Pathways

Interferon Kappa plays a significant role in the JAK-STAT pathway and the toll-like receptor signaling pathway. The JAK-STAT pathway helps to mediate immune response by facilitating communication between cytokines and cell membranes through phosphorylation events. Interferon Kappa influences signals that activate STAT proteins which then move to the cell nucleus and drive antiviral defenses. It also interacts with proteins like STAT1 and STAT2 which are vital components of this response cascade further enhancing its role in cellular defense.

Research shows that Interferon Kappa relates closely with psoriasis and lupus. In psoriasis abnormal Interferon Kappa activity contributes to the dysregulated immune response that characterizes the disease linking it with other interferon-related molecules. Similarly in lupus overexpression or dysregulation can exacerbate the inflammatory processes as it ties closely with upstream proteins in the interferon signaling pathway such as IFN-alpha. Understanding these relationships provides insight into potential therapeutic strategies targeting this specific interferon in disease management.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.
See full target information IFNK
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of immunology research 2020:5084682 PubMed32352019

2020

Interferon Kappa Is Important for Keratinocyte Host Defense against Herpes Simplex Virus-1.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Li,Yueqi Song,Leqing Zhu,Xiao Wang,Brittany Richers,Donald Y M Leung,Lianghua Bin

Clinical, cosmetic and investigational dermatology 12:865-873 PubMed31819584

2019

Interferon Kappa Is Up-Regulated in Psoriasis and It Up-Regulates Psoriasis-Associated Cytokines in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Li,Yueqi Song,Leqing Zhu,Xiao Wang,Bin Yang,Ping Lu,Quan Chen,Lianghua Bin,Liehua Deng

Journal of virology 91: PubMed28768860

2017

Zinc Finger-Containing Cellular Transcription Corepressor ZBTB25 Promotes Influenza Virus RNA Transcription and Is a Target for Zinc Ejector Drugs.

Applications

Unspecified application

Species

Unspecified reactive species

Shu-Chuan Chen,King-Song Jeng,Michael M C Lai
View all publications
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