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AB281100

Anti-IFNW1 antibody [EPR23249-19] - BSA and Azide free (Detector)

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Rabbit Recombinant Monoclonal IFNW1 antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

View Alternative Names

Interferon omega-1, Interferon alpha-II-1, IFNW1

1 Images
Sandwich ELISA - Anti-IFNW1 antibody [EPR23249-19] - BSA and Azide free (Detector) (AB281100)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-IFNW1 antibody [EPR23249-19] - BSA and Azide free (Detector) (AB281100)

Example of Human Interferon omega standard curve. Background-subtracted data values (mean +/- SD) are graphed.

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR23249-19

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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Product details

ab281100 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human Interferon omega (IFNW1). The recommended pair for sandwich ELISA is:
Capture: ab281250, Human Interferon omega (IFNW1) Capture Antibody (unconjugated)
Detector: ab281100, Human Interferon omega (IFNW1) Detector Antibody (unconjugated)
The reference range value is 37.5 - 2400 pg/ml.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IFNW1 also known as interferon omega is a type I interferon with a mass of approximately 23 kDa. Mechanically this protein functions in the immune response by inducing antiviral state in cells. It is expressed in various tissues including immune cells like leukocytes. IFNW1 binds to the specific interferon alpha/beta receptor (IFNAR) to exert its effects. This interaction triggers signaling cascades that activate the transcription of interferon-stimulated genes which are critical in antiviral defense.
Biological function summary

IFNW1 plays important roles in modulating the immune response and controlling viral infections. It is not part of a known protein complex but interacts with IFNAR to activate signaling pathways. It enhances the expression of antiviral proteins and cells' ability to combat pathogen intrusions. Beyond antiviral activity IFNW1 can influence cell differentiation and the immune system's surveillance capabilities ensuring its response against threats is effective.

Pathways

IFNW1 contributes to the JAK-STAT signaling pathway and the innate immune response. In the JAK-STAT pathway it activates key proteins such as JAK1 and TYK2 which lead to phosphorylation and activation of STAT proteins. These activated STAT proteins then translocate to the nucleus and promote transcription of genes involved in antiviral defense. IFNW1 shares pathways with other interferons like IFNA and IFNB making it an integral part of the cytokine signaling network that regulates immune function.

IFNW1 has associations with viral infections and autoimmune disorders like systemic lupus erythematosus (SLE). Its role in antiviral defense positions IFNW1 as a target for understanding virus-host interactions that contribute to pathogenesis. In autoimmune disorders like SLE the dysregulation of interferon signaling including that involving IFNW1 links to the aberrant immune activation seen in these conditions. IFNW1's interactions with IFNA and IFNB highlight its involvement in pathways that can drive disease states emphasizing its relevance in disease research and potential therapeutic approaches.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information IFNW1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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