Anti-IFT46 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

IFT46 also known as Intraflagellar Transport 46 is a component of the intraflagellar transport (IFT) complex B. It plays a mechanical role in the assembly and maintenance of cilia and flagella by transporting cargo along the axonemal microtubules. IFT46 has a molecular mass of approximately 41 kDa. This protein is generally expressed in cells possessing cilia or flagella such as those in the respiratory tract and reproductive system.

Biological function summary

IFT46 interacts with other IFT complex B proteins to facilitate efficient transport within cilia and flagella. It acts as a linker that binds both the IFT-B complex and cargo ensuring proper docking and transport. IFT46 forms part of a complex that includes proteins like IFT52 and IFT88 which are integral for the regular functioning of ciliary transport.

Pathways

IFT46 participates in the intraflagellar transport pathway that is essential for cilia formation and maintenance. IFT46 operates in conjunction with proteins such as IFT52 and IFT81 which are also part of the IFT-B complex within this pathway. This pathway is important for the Hedgehog signaling pathway closely tied to developmental signaling and cellular homeostasis.

Associated diseases and disorders

IFT46 mutations or malfunctions have been linked to ciliopathies such as Joubert syndrome and Bardet-Biedl syndrome. These disorders arise from defective ciliary function. In the context of Joubert syndrome IFT proteins like IFT88 and IFT172 may also be involved indicating shared molecular pathways and potential shared therapeutic targets.