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AB128791

Anti-IgA1 antibody [B3506B4]

5

(1 Review)

|

(1 Publication)

Mouse Monoclonal IGHA1 antibody. Suitable for ELISA, WB, IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Full Length Protein corresponding to Human IGHA1.

View Alternative Names

Immunoglobulin heavy constant alpha 1, Ig alpha-1 chain C region, Ig alpha-1 chain C region BUR, Ig alpha-1 chain C region TRO, IGHA1

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

B3506B4

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB, ELISA, IHC-Fr

applications

Immunogen

Full Length Protein corresponding to Human IGHA1. The exact immunogen used to generate this antibody is proprietary information.

P01876

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Alternative Products

Primary Antibodies

AB193187

Anti-Human IgA1 antibody [RM124]

Recombinant

ELISA - Anti-Human IgA1 antibody [RM124] (AB193187)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB124716

Anti-IgA antibody [EPR5367-76]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IgA antibody [EPR5367-76] (AB124716)

  • 5
  • 2
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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  • 20
Primary Antibodies

AB212201

Anti-Human IgM antibody [EPR20731]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Human IgM antibody [EPR20731] (AB212201)

  • 0
  • 0
Primary Antibodies

AB134050

Anti-IgG2 antibody [EPR4418]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-IgG2 antibody [EPR4418] (AB134050)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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Product details

REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
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Properties and storage information

Form
Liquid
Storage buffer
Constituents: 1% Boric Acid, 0.891% Sodium borate
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IgA1 also known as Immunoglobulin A1 is an important component of the immune system. This protein mainly exists in mucous membranes where it plays an important role in immune function. IgA1 has a mass of approximately 160 kDa and is expressed in various tissues including the respiratory and gastrointestinal tracts. IgA1 is a subclass of immunoglobulin A (IgA) and is characterized by its heavy chain constant region which distinguishes it from other immunoglobulin subclasses.
Biological function summary

IgA1 acts as a first line of defense in the immune system by binding to pathogens and neutralizing them. It exists as a monomer or forms a dimer with the help of the J chain which stabilizes its dimeric form. IgA1 also interacts with the polymeric immunoglobulin receptor (pIgR) for transportation across epithelial cells. This transport allows IgA1 to be present in secretory fluids such as saliva and breast milk providing an important protective function.

Pathways

IgA1 interacts with several pathways involved in immune response and mucosal immunity. One critical pathway is the mucosal antibody response where IgA1 plays a role in preventing infection at mucosal surfaces. The IgA1 protein activates the alternative complement pathway by binding to complement protein C3 which enhances the removal of pathogens. Furthermore IgA1 is associated with the J chain and pIgR in the process of IgA transcytosis across epithelial barriers.

IgA1 has strong connections to IgA nephropathy and celiac disease. In IgA nephropathy IgA1 deposits in glomeruli leading to inflammation and kidney damage. The increased serum levels of IgA1 often with aberrant glycosylation contribute to disease development. In celiac disease IgA1 reacts with tissue transglutaminase causing an immune response that damages the small intestine's lining. In both disorders the interactions between IgA1 and other proteins such as tissue transglutaminase in celiac disease highlight its involvement in pathological processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed : 20176268, PubMed : 22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed : 17576170, PubMed : 20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed : 2241915).
See full target information IGHA1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 12:e0178352 PubMed28552941

2017

CCL20 secreted from IgA1-stimulated human mesangial cells recruits inflammatory Th17 cells in IgA nephropathy.

Applications

Unspecified application

Species

Unspecified reactive species

Guoyuan Lu,Xiaopan Zhang,Lei Shen,Qing Qiao,Yuan Li,Jieqiong Sun,Jinping Zhang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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