AB70545

Anti-IGBP1 antibody

Name: Anti-IGBP1 antibody (ab70545) | Abcam
Brand: Abcam Limited
SKU: AB70545
Price: 545 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(2 Publications)

Rabbit Polyclonal IGBP1 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human IGBP1.

View Alternative Names

IBP1, IGBP1, Immunoglobulin-binding protein 1, B-cell signal transduction molecule alpha 4, CD79a-binding protein 1, Protein phosphatase 2/4/6 regulatory subunit, Renal carcinoma antigen NY-REN-16, Protein alpha-4

2 Images

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Immunoprecipitation - Anti-IGBP1 antibody (AB70545)

1mg whole cell lysate from Ramos cells was immunoprecipitated with ab70545 at 3ug/mg of lysate (lane

or a control rabbit Ig (lane 2). For the subsequent blot 25% of the immunoprecipitate was loaded per lane, and probed with ab70545 at 1ug/ml.

All lanes:

Immunoprecipitation - Anti-IGBP1 antibody (ab70545)

Predicted band size: 39 kDa

false

Unknown

Western blot - Anti-IGBP1 antibody (AB70545)

All lanes:

Western blot - Anti-IGBP1 antibody (ab70545) at 0.4 µg/mL

Lane 1:

Whole cell lysate from Ramos cells at 50 µg

Lane 2:

Whole cell lysate from K562 cells at 50 µg

Lane 3:

Whole cell lysate from NIH3T3 cells at 50 µg

Predicted band size: 39 kDa

Observed band size: 42 kDa

true

Exposure time: 30s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IP, WB

applications

Immunogen

Synthetic Peptide within Human IGBP1. The exact immunogen used to generate this antibody is proprietary information.

P78318

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chicken": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Turkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: PBS, 1.815% Tris, 1.764% Sodium citrate

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Insulin-like Growth Factor Binding Protein 1 (IGBP1) is a multifunctional protein involved in various cellular processes. It is also known as IGFBP-1 and has a molecular mass of approximately 31 kDa. IGBP1 is widely expressed in human tissues with higher levels detected in the liver and the endometrium. The protein plays a role in modulating the availability of insulin-like growth factors (IGFs) by binding to them affecting their function and stability within the body.

Biological function summary

Many cellular processes involve IGBP1 as it binds with insulin-like growth factors to modulate their actions effectively acting as a regulator within the IGF system. IGBP1 may influence cell growth survival and metabolism. It often interacts with other proteins within an IGF-binding complex allowing it to perform various regulatory functions that impact both normal and pathological conditions.

Pathways

Several signaling pathways incorporate the activities of IGBP1 particularly the insulin-like growth factor signaling pathway and the PI3K/AKT pathway. IGBP1 interacts with other proteins such as IGF1R and IRS-1 affecting downstream signaling that governs aspects of cell proliferation and survival. These interactions position IGBP1 as an important regulatory molecule in these pathways influencing cellular responses to IGFs.

Research has linked abnormal levels or activities of IGBP1 with conditions such as diabetes and cancer. IGBP1's modulation of the insulin-like growth factors may affect insulin sensitivity and glucose metabolism contributing to diabetes pathogenesis. In cancer altered IGBP1 expression can influence tumor growth and progression where its relationship with IGF1 and IGF2 is significant in the context of growth factors and their signaling pathways.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.

See full target information IGBP1

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of biomedical science 31:74 PubMed39014450

2024

BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability.

Applications

Unspecified application

Species

Unspecified reactive species

Maria P Silva,Luísa T Ferreira,Natércia F Brás,Lurdes Torres,Andreia Brandão,Manuela Pinheiro,Marta Cardoso,Adriana Resende,Joana Vieira,Carlos Palmeira,Gabriela Martins,Miguel Silva,Carla Pinto,Ana Peixoto,João Silva,Rui Henrique,Sofia Maia,Helder Maiato,Manuel R Teixeira,Paula Paulo

Genes 11: PubMed33255998

2020

Profiling Novel Alternative Splicing within Multiple Tissues Provides Useful Insights into Porcine Genome Annotation.

Applications

Unspecified application

Species

Unspecified reactive species

Wen Feng,Pengju Zhao,Xianrui Zheng,Zhengzheng Hu,Jianfeng Liu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IGBP1 antibody

Immunoprecipitation - Anti-IGBP1 antibody (AB70545)

Western blot - Anti-IGBP1 antibody (AB70545)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise