AB18954

Anti-IGF2 antibody

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(2 Publications)

Rabbit Polyclonal IGF2 antibody. Suitable for WB, sELISA and reacts with Recombinant full length protein - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IGF2.

View Alternative Names

IGF-2, PP1446, IGF2, Insulin-like growth factor 2, Insulin-like growth factor II, Somatomedin-A, T3M-11-derived growth factor, IGF-II

2 Images

Supplier Data

Western blot - Anti-IGF2 antibody (AB18954)

Western blot analysis of IGF-II using recombinant human IGF-II.

Lane 1;50ng

Lane 2;250 ng

Lane 3;500 ng

All lanes:

Western blot - Anti-IGF2 antibody (ab18954)

Predicted band size: 20 kDa

false

Sandwich ELISA - Anti-IGF2 antibody (AB18954)

sELISA

Unknown

Sandwich ELISA - Anti-IGF2 antibody (AB18954)

Standard Curve for IGF2 (Analyte : ab9575) dilution range 1pg/ml to 1ug/ml using Capture Antibody Rat monoclonal [RM0100-3J42] to IGF2 (ab86485) at 1ug/ml and Detector Antibody Rabbit polyclonal to IGF2 (ab18954) at 0.5ug/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Applications

WB, sELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human IGF2.

P01344

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-4 µg/mL", "WB-species-notes": "<p></p>", "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "0.5 µg/mL", "sELISA-species-notes": "<p>For sandwich ELISA, use this antibody as Detection at 0.5μg/ml with <a href='/en-us/products/primary-antibodies/igf2-antibody-rm0100-3j42-ab86485'>ab86485</a> as Capture.</p>" } } }

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 5122 IGF-II Antibody. 5122-100 is the same size as the 100 µg size of ab18954.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed : 28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.

See full target information IGF2

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Inflammopharmacology 33:3479-3498 PubMed40325262

2025

Empagliflozin and memantine combination ameliorates cognitive impairment in scopolamine + heavy metal mixture-induced Alzheimer's disease in rats: role of AMPK/mTOR, BDNF, BACE-1, neuroinflammation, and oxidative stress.

Applications

Unspecified application

Species

Unspecified reactive species

Ebtsam S Abdel-Lah,Hoda S Sherkawy,Wafaa H Mohamed,Mariam A Fawy,Asmaa A Hasan,Asmaa A Muhammed,Amira F Taha,Abeer A Tony,Nashwa Hamad,Marwa G Gamea

International journal of biological sciences 16:2938-2950 PubMed33061807

2020

Lnc-MCEI mediated the chemosensitivity of esophageal squamous cell carcinoma via miR-6759-5p to competitively regulate IGF2.

Applications

Unspecified application

Species

Unspecified reactive species

Guangming Liu,Wei Guo,Guang Chen,Wencan Li,Youbin Cui,Junjie Qin,Jing Peng

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IGF2 antibody

Western blot - Anti-IGF2 antibody (AB18954)

Sandwich ELISA - Anti-IGF2 antibody (AB18954)

Key facts

Host species

Clonality

Isotype

Carrier free

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (2)

Product promise