AB262713

Anti-IGF2 antibody

Name: Anti-IGF2 antibody (ab262713) | Abcam
Brand: Abcam Limited
SKU: AB262713
Price: 220 USD
Availability: InStock

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(7 Publications)

Rabbit Polyclonal IGF2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications.

View Alternative Names

IGF-2, PP1446, IGF2, Insulin-like growth factor 2, Insulin-like growth factor II, Somatomedin-A, T3M-11-derived growth factor, IGF-II

3 Images

Supplier Data

Western blot - Anti-IGF2 antibody (AB262713)

Samples were separated by 12% SDS-PAGE.

All lanes:

Western blot - Anti-IGF2 antibody (ab262713) at 1/1000 dilution

Lane 1:

HepG2 whole cell extract at 30 µg

Lane 2:

HepG2 whole cell extract with conditioned medium at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 20 kDa

false

Supplier Data

Western blot - Anti-IGF2 antibody (AB262713)

Samples were separated by 7.5% SDS-PAGE.

All lanes:

Western blot - Anti-IGF2 antibody (ab262713) at 1/1000 dilution

Lane 1:

Non-transfected 293T whole cell lysates at 30 µg

Lane 2:

Myc-tag tagged IGF2 transfected 293T whole cell lysates at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 20 kDa

false

Supplier Data

Western blot - Anti-IGF2 antibody (AB262713)

Samples were separated by 15% SDS-PAGE.

All lanes:

Western blot - Anti-IGF2 antibody (ab262713) at 1/2000 dilution

Lane 1:

Recombinant IGF2 protein at 10 ng

Lane 2:

Recombinant IGF2 protein at 50 ng

Lane 3:

Recombinant IGF2 protein at 250 ng

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 20 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed : 28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.

See full target information IGF2

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Experimental dermatology 33:e15078 PubMed38610097

2024

Lithium chloride promotes mesenchymal-epithelial transition in murine cutaneous wound healing via inhibiting CXCL9 and IGF2.

Applications

Unspecified application

Species

Unspecified reactive species

Chong Zhang,Xiao Luo,Mianxing Wei,Bingshuai Jing,Jue Wang,Lanling Lin,Bing Shi,Qian Zheng,Chenghao Li

PNAS nexus 2:pgad215 PubMed37416873

2023

Runx1 regulates critical factors that control uterine angiogenesis and trophoblast differentiation during placental development.

Applications

Unspecified application

Species

Unspecified reactive species

Athilakshmi Kannan,Jacob R Beal,Alison M Neff,Milan K Bagchi,Indrani C Bagchi

Medicine 102:e32862 PubMed36749274

2023

Urinary insulin signaling pathway related proteins may serve as potential biomarkers for monitoring diabetes mellitus without hypertension and hyperlipidemia.

Applications

Unspecified application

Species

Unspecified reactive species

Man Zhao,Qian Meng,Man Zhang

Journal of clinical and translational hepatology 11:787-799 PubMed37408817

2023

IGF2-NR4A2 Signaling Regulates Macrophage Subtypes to Attenuate Liver Cirrhosis.

Applications

Unspecified application

Species

Unspecified reactive species

Lichao Yao,Xue Hu,Mengqin Yuan,Qiuling Zhang,Pingji Liu,Lian Yang,Kai Dai,Yingan Jiang

Biomedicines 11: PubMed36672654

2023

Impact of Hypermannosylation on the Structure and Functionality of the ER and the Golgi Complex.

Applications

Unspecified application

Species

Unspecified reactive species

Patricia Franzka,Svenja Caren Schüler,Takfarinas Kentache,Robert Storm,Andrea Bock,Istvan Katona,Joachim Weis,Katrin Buder,Christoph Kaether,Christian A Hübner

Nature communications 13:2083 PubMed35440587

2022

Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes.

Applications

Unspecified application

Species

Unspecified reactive species

Norman L Lehman,Nathalie Spassky,Müge Sak,Amy Webb,Cory T Zumbar,Aisulu Usubalieva,Khaled J Alkhateeb,Joseph P McElroy,Kirsteen H Maclean,Paolo Fadda,Tom Liu,Vineela Gangalapudi,Jamie Carver,Zied Abdullaev,Cynthia Timmers,John R Parker,Christopher R Pierson,Bret C Mobley,Murat Gokden,Eyas M Hattab,Timothy Parrett,Ralph X Cooke,Trang D Lehman,Stefan Costinean,Anil Parwani,Brian J Williams,Randy L Jensen,Kenneth Aldape,Akshitkumar M Mistry

Cell reports 32:108007 PubMed32783935

2020

Runx2+ Niche Cells Maintain Incisor Mesenchymal Tissue Homeostasis through IGF Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Shuo Chen,Junjun Jing,Yuan Yuan,Jifan Feng,Xia Han,Quan Wen,Thach-Vu Ho,Chelsea Lee,Yang Chai

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IGF2 antibody

Western blot - Anti-IGF2 antibody (AB262713)

Western blot - Anti-IGF2 antibody (AB262713)

Western blot - Anti-IGF2 antibody (AB262713)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (7)

Product promise