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AB63984

Anti-IGF2 antibody

3

(3 Reviews)

|

(5 Publications)

Rabbit Polyclonal IGF2 antibody. Suitable for WB, IHC-P, IHC-Fr and reacts with Mouse samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Mouse Igf2.

View Alternative Names

Igf-2, Igf2, Insulin-like growth factor 2, Insulin-like growth factor II, Multiplication-stimulating polypeptide, IGF-II

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-Fr, WB, IHC-P

applications

Immunogen

Synthetic Peptide within Mouse Igf2. The exact immunogen used to generate this antibody is proprietary information.

P09535

Specificity

Mouse 20kDa IGF2 protein.Cross reacts with rat protein. Low cross reactivity was observed with human IGF2 protein.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The insulin-like growth factors possess growth-promoting activity (PubMed : 29440408). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable) (PubMed : 12087403, PubMed : 2330056). IGF2 is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (By similarity). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (PubMed : 16901893). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (PubMed : 32557799).. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
See full target information Igf2
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 24: PubMed34184083

2021

M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Lv,Chao Liu,Fu-Kun Chen,Zhi-Ping Feng,Li Jia,Peng-Jie Liu,Zhi-Xian Yang,Fei Hou,Zhi-Yong Deng

Reproduction (Cambridge, England) 160:905-917 PubMed33112793

2020

Ligustrazine-induced microRNA-16-5p inhibition alleviates preeclampsia through IGF-2.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Yuan,Ling Zhao,Xiaoying Wang,Feng Lian,Yan Cai

Cell biology international 44:1860-1869 PubMed32437062

2020

Long noncoding RNA Airn protects podocytes from diabetic nephropathy lesions via binding to Igf2bp2 and facilitating translation of Igf2 and Lamb2.

Applications

Unspecified application

Species

Unspecified reactive species

Fengying Jing,Jin Zhao,Xu Jing,Gao Lei

BMC neuroscience 13:58 PubMed22672618

2012

Decreased expression of extracellular matrix proteins and trophic factors in the amygdala complex of depressed mice after chronic immobilization stress.

Applications

IHC-Fr

Species

Mouse

Soonwoong Jung,Younghyurk Lee,Gyeongwha Kim,Hyeonwi Son,Dong Hoon Lee,Gu Seob Roh,Sang Soo Kang,Gyeong Jae Cho,Wan Sung Choi,Hyun Joon Kim

American journal of physiology. Gastrointestinal a 298:G551-62 PubMed20133951

2010

Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: critical role of p38MAPK.

Applications

Neut

Species

Rat

Pomila Singh,Shubhashish Sarkar,Shahid Umar,William Rengifo-Cam,Amar P Singh,Thomas G Wood
View all publications
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Product promise

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