Rabbit Polyclonal IGF2BP2/IMP-2 antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human IGF2BP2 aa 500 to C-terminus.
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Publications
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- International journal of oncology 62:2023VIM‑AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2‑mediated HMGCS1 mRNA stabilization.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSheng-Jia Shi,Dong-Hui Han,Jing-Liang Zhang,Yu Li,An-Gang Yang,Rui ZhangPubMed 36734275
- Bioengineered 12:11267-112762021Insulin-like growth factor 2 mRNA binding protein 2 regulates proliferation, migration, and angiogenesis of keratinocytes by modulating heparanase stability.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShaomin Zhi,Jun Li,Xiao Kong,Xuemei Xie,Qiangli Zhang,Guoxiang FangPubMed 34753397
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7 - 8
Preservative: 0.09% Sodium azide
Constituents: 99% Tris citrate/phosphate- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human IGF2BP2 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y6M1
Reactivity data
Select an application| IP | WB | IHC-P | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
| Chimpanzee | Predicted | Predicted | Predicted |
| Cow | Predicted | Predicted | Predicted |
| Dog | Predicted | Predicted | Predicted |
| Gorilla | Predicted | Predicted | Predicted |
| Horse | Predicted | Predicted | Predicted |
| Pig | Predicted | Predicted | Predicted |
| Rabbit | Predicted | Predicted | Predicted |
| Rhesus monkey | Predicted | Predicted | Predicted |
IP
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 2.00000-10.00000 µg/mg of lysate | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rabbit, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Horse | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/2000.00000 - 1/10000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rabbit, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Horse | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/2000.00000 | Notes Epitope retrieval with citrate buffer pH 6.0 is recommended. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rabbit, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Horse | Dilution info - | Notes - |
Associated Products
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Target data
Function
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed:9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152).
Alternative names
IMP2, VICKZ2, IGF2BP2, Insulin-like growth factor 2 mRNA-binding protein 2, IGF2 mRNA-binding protein 2, IMP-2, Hepatocellular carcinoma autoantigen p62, IGF-II mRNA-binding protein 2, VICKZ family member 2
Recommended products
Rabbit Polyclonal IGF2BP2/IMP-2 antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human IGF2BP2 aa 500 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7 - 8
Preservative: 0.09% Sodium azide
Constituents: 99% Tris citrate/phosphate- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human IGF2BP2 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y6M1
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
3 product images
Western blot - Anti-IGF2BP2/IMP-2 antibody (ab117809)
All lanes: Western blot - Anti-IGF2BP2/IMP-2 antibody (ab117809) at 0.1 µg/mL
Lane 1: Whole cell lysate from 293T cells at 50 µg
Lane 2: Whole cell lysate from 293T cells at 15 µg
Lane 3: Whole cell lysate from Jurkat cells at 50 µg
Lane 4: Whole cell lysate from HeLa cells at 50 µg
Developed using the ECL technique.
Predicted band size: 66 kDa
Exposure time: 3min
Immunoprecipitation - Anti-IGF2BP2/IMP-2 antibody (ab117809)
ab117809 at 1 μg/ml staining IGF2BP2/IMP-2 by WB, following immunoprecipitation of whole cell lysate from 293T cells.
Lane 1; IP using an antibody to an upstream epitope.
Lane 2; IP using ab117809 at 6 μg/mg lysate.
Lane 3; IP using control IgG.
1 mg of lysate was used for IP and 20% of IP was loaded. Detection utilised ECL with a 30 second exposure.All lanes: Immunoprecipitation - Anti-IGF2BP2/IMP-2 antibody (ab117809)
Predicted band size: 66 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IGF2BP2/IMP-2 antibody (ab117809)
Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung tissue sections using ab117809 at 1/1000 dilution.
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