AB180948

Anti-IGFBP1 antibody [EPR14471(B)]

RabMAb
Recombinant
What is this?

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(6 Publications)

Rabbit Recombinant Monoclonal IGFBP1 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications.

View Alternative Names

IBP1, IGFBP1, Insulin-like growth factor-binding protein 1, IBP-1, IGF-binding protein 1, IGFBP-1, Placental protein 12, PP12

2 Images

Supplier Data

Western blot - Anti-IGFBP1 antibody [EPR14471(B)] (AB180948)

All lanes:

Western blot - Anti-IGFBP1 antibody [EPR14471(B)] (ab180948) at 1/20000 dilution

All lanes:

HepG2 cell lysate at 20 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 28 kDa

Observed band size: 28 kDa

false

Supplier Data

Western blot - Anti-IGFBP1 antibody [EPR14471(B)] (AB180948)

All lanes:

Western blot - Anti-IGFBP1 antibody [EPR14471(B)] (ab180948) at 1/5000 dilution

Lane 1:

Human fetal liver lysate at 20 µg

Lane 2:

Human placenta lysate at 20 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 28 kDa

Observed band size: 28 kDa

false

Carrier free

Anti-IGFBP1 antibody [EPR14471(B)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR14471(B)

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed : 11397844, PubMed : 15972819). Plays also a positive role in cell migration by interacting with integrin ITGA5 : ITGB1 through its RGD motif (PubMed : 7504269). Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (PubMed : 11397844). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (By similarity).

See full target information IGFBP1

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Journal of ovarian research 17:31 PubMed38310251

2024

Hyperinsulinemia impairs decidualization via AKT-NR4A1 signaling: new insight into polycystic ovary syndrome (PCOS)-related infertility.

Applications

Unspecified application

Species

Unspecified reactive species

Nan-Xing Jiang,Wei-Jie Zhao,Hao-Ran Shen,Dan-Feng Du,Xue-Lian Li

Journal of biomedical science 29:101 PubMed36419076

2022

Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis.

Applications

Unspecified application

Species

Unspecified reactive species

Liyuan Cui,Feng Xu,Chunfang Xu,Yan Ding,Songcun Wang,Meirong Du

Reproduction (Cambridge, England) 162:161-170 PubMed34115609

2021

Melatonin-MT1 signal is essential for endometrial decidualization.

Applications

Unspecified application

Species

Unspecified reactive species

Liyuan Cui,Feng Xu,Songcun Wang,Zhuxuan Jiang,Lu Liu,Yan Ding,Xiaoli Sun,Meirong Du

Journal of advanced research 30:15-25 PubMed34026283

2021

Decreased PIBF1/IL6/p-STAT3 during the mid-secretory phase inhibits human endometrial stromal cell proliferation and decidualization.

Applications

Unspecified application

Species

Unspecified reactive species

Mingjuan Zhou,Huihui Xu,Dan Zhang,Chenchen Si,Xiaowei Zhou,Hui Zhao,Qiang Liu,Bufang Xu,Aijun Zhang

Reproduction (Cambridge, England) 161:573-580 PubMed33780908

2021

TORC2/3-mediated DUSP1 upregulation is essential for human decidualization.

Applications

Unspecified application

Species

Unspecified reactive species

Chunfang Xu,Weijie Zhao,Xixi Huang,Zhuxuan Jiang,Lu Liu,Liyuan Cui,Xinyi Li,Dajin Li,Meirong Du

International journal of oncology 50:883-892 PubMed28197637

2017

Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1α/IGFBP1 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaojiao Gong,Shasha Shen,Yixuan Yang,Si Qin,Lifan Huang,Hongmin Zhang,Ling Chen,Yaqin Chen,Shiying Li,Sha She,Min Yang,Hong Ren,Huaidong Hu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IGFBP1 antibody [EPR14471(B)]

Western blot - Anti-IGFBP1 antibody [EPR14471(B)] (AB180948)

Western blot - Anti-IGFBP1 antibody [EPR14471(B)] (AB180948)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (6)

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