AB7217

Anti-IKB alpha antibody

Name: Anti-IKB alpha antibody (ab7217) | Abcam
Brand: Abcam Limited
SKU: AB7217
Rating: 4 (13 reviews)

(13 Reviews)

(84 Publications)

Rabbit Polyclonal IKB alpha antibody. Suitable for WB and reacts with Mouse samples. Cited in 84 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Nfkbia.

View Alternative Names

Ikba, Nfkbia, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha

1 Images

Supplier Data

Western blot - Anti-IKB alpha antibody (AB7217)

All lanes:

Western blot - Anti-IKB alpha antibody (ab7217) at 1/2000 dilution

All lanes:

Mouse brain tissue lysate

Predicted band size: 35 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Nfkbia.

Q9Z1E3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 6.5 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed : 10097128, PubMed : 9990853). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed : 10097128, PubMed : 7878466, PubMed : 9990853).

See full target information Nfkbia

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Publications (84)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed36499700

2022

Extracellular Acidosis Differentially Regulates Estrogen Receptor β-Dependent EMT Reprogramming in Female and Male Melanoma Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Silvia Peppicelli,Jessica Ruzzolini,Matteo Lulli,Alessio Biagioni,Francesca Bianchini,Adele Caldarella,Chiara Nediani,Elena Andreucci,Lido Calorini

Journal of Cancer 13:1958-1971 PubMed35399722

2022

Suppression of CCT3 inhibits melanoma cell proliferation by downregulating CDK1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Wenlou Liu,Xiuli Zhang,Cheng Chen,Yizhi Li,Chunsheng Yang,Zhengxiang Han,Guan Jiang,Yanqun Liu

Frontiers in pharmacology 12:763160 PubMed35111047

2022

Activation of Autophagy Through the NLRP3/mTOR Pathway: A Potential Mechanism for Alleviation of Pneumonia by QingFei Yin.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaozhou Sun,Dandan Wang,Lizhong Ding,Yan Xu,Wenxiu Qi,Daqing Zhao,Li Liu,Chengcheng Yin,Changsheng Cui,Zhongtian Wang,Liwei Sun,Liping Sun

Oxidative medicine and cellular longevity 2021:9247947 PubMed34938383

2021

Geniposide Attenuates Hyperglycemia-Induced Oxidative Stress and Inflammation by Activating the Nrf2 Signaling Pathway in Experimental Diabetic Retinopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Tu,Lele Li,Linling Zhu,Yang Guo,Shu Du,Yuxing Zhang,Zhenzhen Wang,Yuting Zhang,Manhui Zhu

Frontiers in cellular and infection microbiology 11:791466 PubMed34950611

2021

Gut Microbiota and SCFAs Play Key Roles in QingFei Yin Recipe Anti- Pneumonia Effects.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaozhou Sun,Dandan Wang,Lina Wei,Lizhong Ding,Yinan Guo,Zhongtian Wang,Yibu Kong,Jingjing Yang,Liwei Sun,Liping Sun

Molecular medicine reports 24: PubMed34490475

2021

Remote ischemic post‑conditioning alleviates ischemia/reperfusion‑induced intestinal injury via the ERK signaling pathway‑mediated RAGE/HMGB axis.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Mi,Nan Zhang,Jiyun Wan,Ming Cheng,Jianping Liao,Xiao Zheng

Molecular carcinogenesis 60:567-581 PubMed34101920

2021

Anticancer activities of parthenolide in primary effusion lymphoma preclinical models.

Applications

Unspecified application

Species

Unspecified reactive species

Louna Karam,Soumaiah Abou Staiteieh,Rady Chaaban,Berthe Hayar,Bassel Ismail,Frank Neipel,Nadine Darwiche,Raghida Abou Merhi

Experimental and therapeutic medicine 22:795 PubMed34093751

2021

miR-9 alleviated the inflammatory response and apoptosis in caerulein-induced acute pancreatitis by regulating FGF10 and the NF-κB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Shen,Chengjun Xue,Guoli You,Cui Liu

Frontiers in pharmacology 12:648688 PubMed34054527

2021

Liquiritin Attenuates Lipopolysaccharides-Induced Cardiomyocyte Injury via an AMP-Activated Protein Kinase-Dependent Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Shan-Qi Mou,Zi-Ying Zhou,Hong Feng,Nan Zhang,Zheng Lin,Xiahenazi Aiyasiding,Wen-Jing Li,Wen Ding,Hai-Han Liao,Zhou-Yan Bian,Qi-Zhu Tang

Translational oncology 14:101114 PubMed33975179

2021

XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IkB.

Applications

Unspecified application

Species

Unspecified reactive species

Basia Galinski,Marcus Luxemburg,Yosef Landesman,Bruce Pawel,Katherine J Johnson,Stephen R Master,Kevin W Freeman,David M Loeb,Jean M Hébert,Daniel A Weiser

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IKB alpha antibody

Western blot - Anti-IKB alpha antibody (AB7217)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (84)

Product promise