AB239517

Anti-IL-1 alpha antibody [C1]

Name: Anti-IL-1 alpha antibody [C1] (ab239517) | Abcam
Brand: Abcam Limited
SKU: AB239517
Price: 525 USD
Availability: InStock

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(9 Publications)

Mouse Monoclonal IL-1 alpha antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 9 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IL1A.

View Alternative Names

IL1F1, IL1A, Interleukin-1 alpha, IL-1 alpha, Hematopoietin-1

6 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-1 alpha antibody [C1] (AB239517)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-1 alpha antibody [C1] (AB239517)

Formalin-fixed, paraffin-embedded human stomach tissue stained for IL-1 alpha with ab239517 at 40 μg/ml in immunohistochemical analysis. DAB staining. HRP-Goat Anti-Mouse IgG secondary antibody was used at 2 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-1 alpha antibody [C1] (AB239517)

Formalin-fixed, paraffin-embedded human prostate tissue stained for IL-1 alpha with ab239517 at 40 μg/ml in immunohistochemical analysis. DAB staining. HRP-Goat Anti-Mouse IgG secondary antibody was used at 2 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-1 alpha antibody [C1] (AB239517)

Formalin-fixed, paraffin-embedded human stomach cancer tissue stained for IL-1 alpha with ab239517 at 40 μg/ml in immunohistochemical analysis. DAB staining. HRP-Goat Anti-Mouse IgG secondary antibody was used at 2 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-1 alpha antibody [C1] (AB239517)

Formalin-fixed, paraffin-embedded human kidney tissue stained for IL-1 alpha with ab239517 at 40 μg/ml in immunohistochemical analysis. DAB staining. HRP-Goat Anti-Mouse IgG secondary antibody was used at 2 μg/ml.

Supplier Data

Western blot - Anti-IL-1 alpha antibody [C1] (AB239517)

All lanes:

Western blot - Anti-IL-1 alpha antibody [C1] (ab239517) at 3 µg/mL

All lanes:

Rat liver tissue lysate

Secondary

All lanes:

HRP-Goat Anti-Mouse IgG at 0.2 µg/mL

Predicted band size: 31 kDa

false

Supplier Data

Western blot - Anti-IL-1 alpha antibody [C1] (AB239517)

All lanes:

Western blot - Anti-IL-1 alpha antibody [C1] (ab239517) at 2 µg/mL

All lanes:

Recombinant human IL-1 alpha protein

Predicted band size: 31 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

Isotype

IgG2b

Light chain type

kappa

Carrier free

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human IL1A.

P01583

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Purification notes

Purified from TCS.

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems (PubMed : 26439902). After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex (PubMed : 17507369, PubMed : 2950091). Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4 (PubMed : 17507369). In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways (PubMed : 14687581). Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage (PubMed : 15679580). In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as a signal for genotoxic stress without loss of cell integrity (PubMed : 26439902).

See full target information IL1A

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in neurology 16:1642150 PubMed40860972

2025

Electroacupuncture enhances mesenchymal stem cell therapy via improved perfusion and inflammation modulation in peripheral nerve injury: an IVIM-MRI study in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Junfeng Li,Qiuyi Chen,Jintong Pan,Fanqi Meng,Wensheng Huang,Yingying Liang,Xuewen Yu,Ruirui Qi,Peiyin Luo,Haodong Qin,Yueyao Chen,Xiaofeng Lin

Scientific reports 15:13923 PubMed40263535

2025

Neutrophils induce astrocytic AQP4 expression via IL-1α and TNF, contributing to cerebral oedema in ischaemic stroke rats.

Applications

Unspecified application

Species

Unspecified reactive species

Kana Sugimoto,Chihpin Yang,Miharu Ono,Mai Shirazaki,Ryuichi Katada,Hiroshi Matsumoto

Journal of neuroinflammation 22:45 PubMed39985048

2025

Cinnamaldehyde and its combination with deferoxamine ameliorate inflammation, ferroptosis and hematoma expansion after intracerebral hemorrhage in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yulin Liu,Guoqiang Yang,Mengnan Liu,Yuwei Zhang,Houping Xu,Maryam Mazhar

Biomedicines 12: PubMed39335502

2024

Inflammaging: Expansion of Molecular Phenotype and Role in Age-Associated Female Infertility.

Applications

Unspecified application

Species

Unspecified reactive species

Dmitry Ivanov,Anna Drobintseva,Valeriia Rodichkina,Ekaterina Mironova,Tatyana Zubareva,Yuliya Krylova,Svetlana Morozkina,Maria Greta Pia Marasco,Gianluigi Mazzoccoli,Ruslan Nasyrov,Igor Kvetnoy

International journal of molecular sciences 25: PubMed39273533

2024

The Disease-Modifying Effects of a Single Intra-Articular Corticosteroid Injection during the Freezing Phase of Frozen Shoulder in an Animal Model.

Applications

Unspecified application

Species

Unspecified reactive species

Yongjin Ahn,Sun-Jae Lee,Yong Suk Moon,Yoon-Jin Lee,Jung Hyun Park,Yongmin Chun,Dong Rak Kwon,Sang Chul Lee

Biomedical optics express 13:6659-6670 PubMed36589582

2022

All-fiber SPR microfluidic chip for GDF11 detection.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Wei,Zhuo Ren,Ze Ran,Rui Wang,Chun-Biao Liu,Chen Shi,Chun-Lan Liu,Chen Wang,Yong-Hui Zhang

Journal of inflammation research 14:5919-5937 PubMed34803390

2021

Melatonin Ameliorates Axonal Hypomyelination of Periventricular White Matter by Transforming A1 to A2 Astrocyte via JAK2/STAT3 Pathway in Septic Neonatal Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Shuqi Jiang,Huifang Wang,Qiuping Zhou,Qian Li,Nan Liu,Zhenggong Li,Chunbo Chen,Yiyu Deng

Frontiers in pharmacology 11:602054 PubMed33551807

2021

Immunomodulatory Effect of Colistin and its Protective Role in Rats with Methicillin-Resistant induced Pneumonia.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Niu,Tianli Yang,Jin Wang,Rui Wang,Yun Cai

Frontiers in immunology 11:594071 PubMed33424842

2020

Maf1 Ameliorates Sepsis-Associated Encephalopathy by Suppressing the NF-B/NLRP3 Inflammasome Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Shenglong Chen,Chaogang Tang,Hongguang Ding,Zhonghua Wang,Xinqiang Liu,Yunfei Chai,Wenqiang Jiang,Yongli Han,Hongke Zeng

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IL-1 alpha antibody [C1]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-1 alpha antibody [C1] (AB239517)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-1 alpha antibody [C1] (AB239517)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-1 alpha antibody [C1] (AB239517)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-1 alpha antibody [C1] (AB239517)

Western blot - Anti-IL-1 alpha antibody [C1] (AB239517)

Western blot - Anti-IL-1 alpha antibody [C1] (AB239517)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

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Secondary Antibodies

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (9)

Product promise