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AB89883

Anti-IL-10RA antibody [MM0359-7Q35]

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(1 Publication)

Mouse Monoclonal IL-10RA antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human IL10RA.

View Alternative Names

CD210, IL10R, IL10RA, Interleukin-10 receptor subunit alpha, IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, Interleukin-10 receptor subunit 1, IL-10R subunit 1, IL-10R1

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0359-7Q35

Isotype

IgG2

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human IL10RA. The exact immunogen used to generate this antibody is proprietary information.

Q13651

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed : 16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed : 12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed : 26962683).
See full target information IL10RA
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of allergy and clinical immunology 143:2190-2201.e9 PubMed30682454

2019

Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid.

Applications

Unspecified application

Species

Unspecified reactive species

Hideaki Morita,Terufumi Kubo,Beate Rückert,Avinash Ravindran,Michael B Soyka,Arturo Ottavio Rinaldi,Kazunari Sugita,Marcin Wawrzyniak,Paulina Wawrzyniak,Kenichiro Motomura,Masato Tamari,Keisuke Orimo,Naoko Okada,Ken Arae,Kyoko Saito,Can Altunbulakli,Francesc Castro-Giner,Ge Tan,Avidan Neumann,Katsuko Sudo,Liam O'Mahony,Kenya Honda,Susumu Nakae,Hirohisa Saito,Jenny Mjösberg,Gunnar Nilsson,Kenji Matsumoto,Mübeccel Akdis,Cezmi A Akdis
View all publications
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