Mouse Monoclonal IL-12B antibody. Suitable for ELISA, IHC-Fr and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IL12A.
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS
| ELISA | IHC-Fr | |
|---|---|---|
| Human | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
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Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
NKSF2, IL12B, Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40, NK cell stimulatory factor chain 2, CLMF p40
Mouse Monoclonal IL-12B antibody. Suitable for ELISA, IHC-Fr and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IL12A.
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS
ab11446 recognises the p40 subunit of human IL-12, and binds to both the free subunit and the p35/p40 heterodimer.
This antibody reacts with both stimulated and unstimulated monocytes in immunohistology.
This product should be stored undiluted.
Storage in frost free freezers is not recommended.
Should this product contain a precipitate we recommend microcentrifugation before use.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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