AB106270

Anti-IL-12 p40 antibody

Name: Anti-IL-12 p40 antibody (ab106270) | Abcam
Brand: Abcam Limited
SKU: AB106270
Price: 535 USD
Availability: InStock

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(8 Publications)

Rabbit Polyclonal IL-12B antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IL12B.

View Alternative Names

NKSF2, IL12B, Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40, NK cell stimulatory factor chain 2, CLMF p40

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-12 p40 antibody (AB106270)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-12 p40 antibody (AB106270)

ab106270 at 1/100 dilution staining IL12 p40 in Human fetal colon by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

Unknown

Western blot - Anti-IL-12 p40 antibody (AB106270)

All lanes:

Western blot - Anti-IL-12 p40 antibody (ab106270) at 1/1000 dilution

All lanes:

Human fetal liver lysate

Predicted band size: 37 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human IL12B.

P29460

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Lyophilized

Reconstitution

reconstitute with water at 200µL

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

See full target information IL12B

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Open veterinary journal 15:3558-3570 PubMed41036017

2025

Host-parasite interaction in latent cerebral toxoplasmosis: The role of cytokine response in a mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Tuğçe Anteplioğlu,Merve Bişkin Türkmen,Erva Eser,Damla Okatan,Oğuz Kul

Children (Basel, Switzerland) 12: PubMed40003307

2025

Immunomodulatory Tissue Factors in the Gallbladder Walls of Pediatric Patients with Chronic Calculous Cholecystitis.

Applications

Unspecified application

Species

Unspecified reactive species

Kaiva Zīle Zariņa,Māra Pilmane,Aigars Pētersons

GEN biotechnology 2:228-246 PubMed37363412

2023

Comparative Evaluation of Synthetic Cytokines for Enhancing Production and Performance of NK92 Cell-Based Therapies.

Applications

Unspecified application

Species

Unspecified reactive species

Simrita Deol,Patrick S Donahue,Roxana E Mitrut,Iva J Hammitt-Kess,Jihae Ahn,Bin Zhang,Joshua N Leonard

Oncology reports 45: PubMed33649843

2021

Downregulation of triggering receptor expressed on myeloid cells 1 inhibits invasion and migration of liver cancer cells by mediating macrophage polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Minmin Chen,Ruimin Lai,Xiaoyu Lin,Wei Chen,Huizhen Wu,Qi Zheng

Theranostics 10:3925-3938 PubMed32226529

2020

IL-23, but not IL-12, plays a critical role in inflammation-mediated bone disorders.

Applications

Unspecified application

Species

Unspecified reactive species

Jiajia Xu,Jiao Li,Yiming Hu,Kerong Dai,Yaokai Gan,Jingyu Zhao,Mingjian Huang,Xiaoling Zhang

Oncology reports 42:370-376 PubMed31115558

2019

Intratumoral injection of dendritic cells overexpressing interleukin‑12 inhibits melanoma growth.

Applications

Unspecified application

Species

Unspecified reactive species

Weirong Yao,Yingliang Li,Lin Zeng,Xiquan Zhang,Zhiyong Zhou,Meixue Zheng,Huiping Wan

Scientific reports 8:5498 PubMed29615652

2018

Interleukin-23 as a therapeutic target for inflammatory myopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Natsuka Umezawa,Kimito Kawahata,Fumitaka Mizoguchi,Naoki Kimura,Yoko Yoshihashi-Nakazato,Nobuyuki Miyasaka,Hitoshi Kohsaka

Oncotarget 5:4671-82 PubMed25015728

2014

Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675 patients.

Applications

Unspecified application

Species

Unspecified reactive species

Melina Helbling,Anne Lukesch,Aladin Haimovici,Eva Karamitopoulou,Martin D Berger,Marion Hädrich,Makhmud Mallaev,Beat Schnüriger,Viktor H Koelzer,Heather Dawson,Markus Borner,Rupert Langer,Robert Rosenberg,Ulrich Nitsche,Daniel Inderbitzin,Alessandro Lugli,Mario Tschan,Inti Zlobec

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IL-12 p40 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-12 p40 antibody (AB106270)

Western blot - Anti-IL-12 p40 antibody (AB106270)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Reconstitution

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (8)

Product promise