AB5984

Anti-IL-22RA1 antibody

Name: Anti-IL-22RA1 antibody (ab5984) | Abcam
Brand: Abcam Limited
SKU: AB5984
Price: 625 USD
Availability: InStock
Rating: 3 (4 reviews)

(4 Reviews)

(23 Publications)

Rabbit Polyclonal IL-22RA1 antibody. Suitable for ICC, WB, IHC-P, ICC/IF and reacts with Human, Rat samples. Cited in 23 publications. Immunogen corresponding to Synthetic Peptide within Human IL22RA1 aa 1-50.

View Alternative Names

IL22R, IL22RA1, Interleukin-22 receptor subunit alpha-1, IL-22 receptor subunit alpha-1, IL-22R-alpha-1, IL-22RA1, Cytokine receptor class-II member 9, Cytokine receptor family 2 member 9, ZcytoR11, CRF2-9

6 Images

Immunocytochemistry/ Immunofluorescence - Anti-IL-22RA1 antibody (AB5984)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-IL-22RA1 antibody (AB5984)

Immunocytochemistry/Immunofluorescence analysis of HepG2 cells labelling IL-22RA1 with ab5984 at 10μg/ml.

Unknown

Immunocytochemistry - Anti-IL-22RA1 antibody (AB5984)

Immunocytochemistry of IL-22R in HepG2 cells with IL-22RA1 antibody at 10 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-22RA1 antibody (AB5984)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-22RA1 antibody (AB5984)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat kidney tissue labelling IL-22RA1 with ab5984 at 5μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-22RA1 antibody (AB5984)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat kidney tissue labelling IL-22RA1 with ab5984 at 20μg/ml.

Unknown

Western blot - Anti-IL-22RA1 antibody (AB5984)

Western blot analysis of IL-22RA1 expression in human HepG2 cell lysate with ab5984 at 1μg /ml. Western blot analysis of IL-22R expression in human HepG2 cell lysate with ab5984 at 1μg /ml.

All lanes:

Western blot - Anti-IL-22RA1 antibody (ab5984)

Predicted band size: 63 kDa

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Supplier Data

Western blot - Anti-IL-22RA1 antibody (AB5984)

Lane 1:

Western blot - Anti-IL-22RA1 antibody (ab5984) at 0.5 µg/mL

Lane 2:

Western blot - Anti-IL-22RA1 antibody (ab5984) at 1 µg/mL

All lanes:

HepG2 cell lysates

Predicted band size: 63 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

WB, ICC/IF, ICC, IHC-P

applications

Immunogen

Synthetic Peptide within Human IL22RA1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q8N6P7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "10 µg/mL", "ICC-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "" }, "Rat": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

IL-22RA1 Antibody is affinity chromatography purified via peptide column.

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle|Stable for 12 months at -20°C

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

See full target information IL22RA1

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Publications (23)

Recent publications for all applications. Explore the full list and refine your search

Molecular and cellular biochemistry 480:3147-3160 PubMed39690293

2024

Interleukin-22 promotes endometrial carcinoma cell proliferation and cycle progression via ERK1/2 and p38 activation.

Applications

Unspecified application

Species

Unspecified reactive species

Shiqi Liu,Ruqian Zhao,Yuqin Zang,Pengzhu Huang,Qiaoling Zhang,Xiangqin Fan,Junyi Bai,Xingyu Zheng,Shuangshuang Zhao,Dan Kuai,Chao Gao,Yingmei Wang,Fengxia Xue

PloS one 18:e0286907 PubMed37319277

2023

Endogenous interleukin-22 prevents cardiac rupture after myocardial infarction in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Mai Yamamoto,Hideo Yasukawa,Jinya Takahashi,Shoichiro Nohara,Tomoko Sasaki,Kodai Shibao,Daiki Akagaki,Kota Okabe,Toshiyuki Yanai,Tatsuhiro Shibata,Yoshihiro Fukumoto

Journal of immunology (Baltimore, Md. : 1950) 209:1768-1777 PubMed36130829

2022

Th17-Derived Cytokines Synergistically Enhance IL-17C Production by the Colonic Epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Stephanie M Swedik,Abson Madola,Michelle A Cruz,Braulio J Llorens-Bonilla,Alan D Levine

Disease markers 2022:4351949 PubMed35756495

2022

Folate Receptor 4-Expressing T cell Is Associated with Disease-Free Survival in Patients with Esophageal Squamous Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangmei Zhang,Qi Zhao,Miao Cao,Xinhui Li,Xin Chen,Ming He,Yunjiang Liu,Jidong Zhao

Journal of biomedical science 29:36 PubMed35681232

2022

Interleukin-20 is involved in dry eye disease and is a potential therapeutic target.

Applications

Unspecified application

Species

Unspecified reactive species

Hsiao-Hsuan Wang,Wei-Yu Chen,Yi-Hsun Huang,Sheng-Min Hsu,Yeou-Ping Tsao,Yu-Hsiang Hsu,Ming-Shi Chang

Frontiers in pharmacology 12:657827 PubMed34045965

2021

Microbiome-Metabolomics Analysis Reveals the Protection Mechanism of -Ketoacid on Adenine-Induced Chronic Kidney Disease in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yenan Mo,Huang Sun,Lei Zhang,Wenjia Geng,Lixin Wang,Chuan Zou,Yuchi Wu,Chunlan Ji,Xusheng Liu,Zhaoyu Lu

EBioMedicine 64:103213 PubMed33508745

2021

Interleukin-24 protects against liver injury in mouse models.

Applications

Unspecified application

Species

Unspecified reactive species

Hsiao-Hsuan Wang,Jian-Hao Huang,Min-Hao Sue,Wei-Chih Ho,Yu-Hsiang Hsu,Kung-Chao Chang,Ming-Shi Chang

Cancer biotherapy & radiopharmaceuticals 36:160-166 PubMed33090014

2020

Tumor Cells Interleukin-22 Expression Associates with Elevated Tumor-Associated Macrophages Infiltrating and Poor Prognosis in Patients with Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jidong Zhao,Hongzhang Liu,Xiangmei Zhang,Wenqing Zhang,Li Liu,Yang Yu,Shuguang Ren,Qing Yang,Beichen Liu,Jingping Li,Xinhui Li,Yunjiang Liu,Liyan Zhao

Experimental and therapeutic medicine 20:2148-2156 PubMed32765690

2020

IL-22/IL-22R1 promotes proliferation and collagen synthesis of MRC-5 cells via the JAK/STAT3 signaling pathway and regulates airway subepithelial fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Liu,Biao Shang,Jing Bai

Journal of the American Heart Association 9:e014814 PubMed32301368

2020

Interleukin-22 Directly Activates Myocardial STAT3 (Signal Transducer and Activator of Transcription-3) Signaling Pathway and Prevents Myocardial Ischemia Reperfusion Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Jinya Takahashi,Mai Yamamoto,Hideo Yasukawa,Shoichiro Nohara,Takanobu Nagata,Koutatsu Shimozono,Toshiyuki Yanai,Tomoko Sasaki,Kota Okabe,Tatsuhiro Shibata,Kazutoshi Mawatari,Tatsuyuki Kakuma,Hiroki Aoki,Yoshihiro Fukumoto

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IL-22RA1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-IL-22RA1 antibody (AB5984)

Immunocytochemistry - Anti-IL-22RA1 antibody (AB5984)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-22RA1 antibody (AB5984)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-22RA1 antibody (AB5984)

Western blot - Anti-IL-22RA1 antibody (AB5984)

Western blot - Anti-IL-22RA1 antibody (AB5984)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Target data

Publications (23)

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