Mouse Monoclonal IL-23 antibody. Carrier free. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IL23A.
Images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-23 antibody [B-Z23] - BSA and Azide free (AB84471), expandable thumbnail](https://content.abcam.com/products/images/il-23-antibody-b-z23-bsa-and-azide-free-ab84471--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img167560.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-23 antibody [B-Z23] - BSA and Azide free (AB84471)")
Publications
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- Frontiers in immunology 8:19592018Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56 Natural Killer Cells and Enhances IL-18-Driven Dendritic Cells Activation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAndrea Ziblat,Sol Y Nuñez,Ximena Lucía Raffo Iraolagoitia,Raúl German Spallanzani,Nicolás I Torres,Jessica M Sierra,Florencia Secchiari,Carolina I Domaica,Mercedes B Fuertes,Norberto W ZwirnerPubMed 29403472
- Carcinogenesis 35:1330-402014IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLe Zhang,Jun Li,Li Li,Jie Zhang,Xiaodong Wang,Chuanhua Yang,Yanyan Li,Feng Lan,Ping LinPubMed 24464786
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
pH: 7.3 - 7.5
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human IL23A. Database link Q9NPF7
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 | Notes - |
Associated Products
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Target data
Function
Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383). Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (PubMed:29287995, PubMed:32474165, PubMed:33606986). This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A (PubMed:12023369). In turn, participates in the early and effective intracellular bacterial clearance (PubMed:32474165). Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed:17676044).
Alternative names
SGRF, UNQ2498/PRO5798, IL23A, Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19
Recommended products
Mouse Monoclonal IL-23 antibody. Carrier free. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IL23A.
Key facts
- Isotype
- IgG1
- Host species
- Mouse
- Storage buffer
pH: 7.3 - 7.5
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human IL23A. Database link Q9NPF7
- Carrier free
- Yes
- Clone number
- B-Z23
- Purification technique
- Ion exchange chromatography
- Specificity
Recognizes both recombinant and natural human IL23, p19 sub-unit.
- Light chain type
- kappa
- Concentration
- Purification notes
Sterile-filtered through 0.22 µm and treated to remove endotoxins.
Inhibits the bioactivity of rhIL-23 on mouse splenocytes C57BI/6 (measurement of mIL-17 or mIL-22 production)
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C, -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-23 antibody [B-Z23] - BSA and Azide free (ab84471), expandable thumbnail](https://content.abcam.com/products/images/il-23-antibody-b-z23-bsa-and-azide-free-ab84471--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img167560.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-23 antibody [B-Z23] - BSA and Azide free (ab84471)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-23 antibody [B-Z23] - BSA and Azide free (ab84471)
Paraffin embedded human psoriasis lesion tissue labelling IL-23 with ab84471 at 1/500 dilution (Red). DAPI (Blue).
Downloads
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