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AB84471

Anti-IL-23 antibody [B-Z23] - BSA and Azide free

5

(1 Review)

|

(2 Publications)

Mouse Monoclonal IL-23 antibody. Carrier free. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IL23A.

View Alternative Names

SGRF, UNQ2498/PRO5798, IL23A, Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-23 antibody [B-Z23] - BSA and Azide free (AB84471)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-23 antibody [B-Z23] - BSA and Azide free (AB84471)

Paraffin embedded human psoriasis lesion tissue labelling IL-23 with ab84471 at 1/500 dilution (Red). DAPI (Blue).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

B-Z23

Isotype

IgG1

Light chain type

kappa

Carrier free

Yes

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human IL23A.

Q9NPF7

Specificity

Recognizes both recombinant and natural human IL23, p19 sub-unit.

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Alternative Products

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Primary Antibodies

AB242923

Anti-Macrophage inflammatory protein 5 antibody [EPR20024-133] - BSA and Azide free (Detector)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Ion exchange chromatography
Purification notes

Sterile-filtered through 0.22 µm and treated to remove endotoxins.

Inhibits the bioactivity of rhIL-23 on mouse splenocytes C57BI/6 (measurement of mIL-17 or mIL-22 production)

Storage buffer
pH: 7.3 - 7.5 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed : 11114383). Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (PubMed : 29287995, PubMed : 32474165, PubMed : 33606986). This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A (PubMed : 12023369). In turn, participates in the early and effective intracellular bacterial clearance (PubMed : 32474165). Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed : 17676044).
See full target information IL23A
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 8:1959 PubMed29403472

2018

Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56 Natural Killer Cells and Enhances IL-18-Driven Dendritic Cells Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Andrea Ziblat,Sol Y Nuñez,Ximena Lucía Raffo Iraolagoitia,Raúl German Spallanzani,Nicolás I Torres,Jessica M Sierra,Florencia Secchiari,Carolina I Domaica,Mercedes B Fuertes,Norberto W Zwirner

Carcinogenesis 35:1330-40 PubMed24464786

2014

IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Le Zhang,Jun Li,Li Li,Jie Zhang,Xiaodong Wang,Chuanhua Yang,Yanyan Li,Feng Lan,Ping Lin
View all publications
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Product promise

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