AB180894

Anti-IL-36R antibody

Name: Anti-IL-36R antibody (ab180894) | Abcam
Brand: Abcam Limited
SKU: AB180894

Be the first to review this product! Submit a review

(7 Publications)

Rabbit Polyclonal IL-36R antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human IL1RL2.

View Alternative Names

IL1RRP2, IL1RL2, Interleukin-1 receptor-like 2, IL-36 receptor, Interleukin-1 receptor-related protein 2, IL-36R, IL-1Rrp2, IL1R-rp2

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-36R antibody (AB180894)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-36R antibody (AB180894)

Immunohistochemical analysis of paraffin-embedded Human small intestine tissue labeling IL1RL2 with ab180894 at 5 μg/ml.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-36R antibody (AB180894)

Immunohistochemical analysis of paraffin-embedded Human small intestine tissue labeling IL1RL2 with ab180894 at 20 μg/ml.

Supplier Data

Western blot - Anti-IL-36R antibody (AB180894)

Lane 1:

Western blot - Anti-IL-36R antibody (ab180894) at 1 µg/mL

Lane 2:

Western blot - Anti-IL-36R antibody (ab180894) at 2 µg/mL

All lanes:

Human small intestine lysate at 15 µg

Predicted band size: 65 kDa

Observed band size: 55 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human IL1RL2. The exact immunogen used to generate this antibody is proprietary information.

Q9HB29

Specificity

ab180894 will detect all three isoforms of IL1RL2. ab180894 is predicted to not cross-react with IL1 Receptor I or ST2.

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

style

left-column

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

See full target information IL1RL2

style

left-column

Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:7662 PubMed39266531

2024

IL36G-producing neutrophil-like monocytes promote cachexia in cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshihiro Hayashi,Yasushige Kamimura-Aoyagi,Sayuri Nishikawa,Rena Noka,Rika Iwata,Asami Iwabuchi,Yushin Watanabe,Natsumi Matsunuma,Kanako Yuki,Hiroki Kobayashi,Yuka Harada,Hironori Harada

British journal of pharmacology 179:4378-4399 PubMed35481896

2022

Modulation of interleukin-36 based inflammatory feedback loop through the hepatocyte-derived IL-36R-P2X7R axis improves steatosis in alcoholic steatohepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Shang,Hong-Xu Yang,Xia Li,Yu Zhang,Nan Chen,Xue-Li Jiang,Zhi-Hong Zhang,Rong-Mei Zuo,Hui Wang,Xiao-Qi Lan,Jie Ren,Yan-Ling Wu,Zhen-Yu Cui,Ji-Xing Nan,Li-Hua Lian

Investigative ophthalmology & visual science 62:10 PubMed33970198

2021

Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis.

Applications

Unspecified application

Species

Unspecified reactive species

Chenyang Dai,Rao Me,Nan Gao,Guanyu Su,Xinyi Wu,Fu-Shin X Yu

Technology in cancer research & treatment 20:1533033821995282 PubMed33602046

2021

The Potential Role of IL1RAP on Tumor Microenvironment-Related Inflammatory Factors in Stomach Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Lv,Qinghua Xia,Anshu Li,Zhiyong Wang

International journal of molecular sciences 22: PubMed33396613

2020

Role of IL-36 Cytokines in the Regulation of Angiogenesis Potential of Trophoblast Cells.

Applications

Unspecified application

Species

Unspecified reactive species

José M Murrieta-Coxca,Ruby N Gutiérrez-Samudio,Heba M El-Shorafa,Tanja Groten,Sandra Rodríguez-Martínez,Mario E Cancino-Diaz,Juan C Cancino-Diaz,Rodolfo R Favaro,Udo R Markert,Diana M Morales-Prieto

Glia 67:438-451 PubMed30578562

2018

Spinal IL-36γ/IL-36R participates in the maintenance of chronic inflammatory pain through astroglial JNK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Li,Shenbin Liu,Lingling Li,Xiaoli Ji,Min Wang,Junmei Zhou

Mucosal immunology 9:1193-204 PubMed26813344

2016

IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

S E Russell,R M Horan,A M Stefanska,A Carey,G Leon,M Aguilera,D Statovci,T Moran,P G Fallon,F Shanahan,E K Brint,S Melgar,S Hussey,P T Walsh

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IL-36R antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-36R antibody (AB180894)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-36R antibody (AB180894)

Western blot - Anti-IL-36R antibody (AB180894)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Alternative Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Complementary Products

Assay Kits

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Product protocols

Target data

Publications (7)

Product promise