Anti-IL-8 antibody [807]
5
(9 Reviews)
|
(71 Publications)
Mouse Monoclonal IL-8 antibody. Suitable for WB and reacts with Human samples. Cited in 71 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CXCL8.
View Alternative Names
IL8, CXCL8, Interleukin-8, IL-8, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8, Emoctakin, Granulocyte chemotactic protein 1, Monocyte-derived neutrophil chemotactic factor, Monocyte-derived neutrophil-activating peptide, Neutrophil-activating protein 1, Protein 3-10C, T-cell chemotactic factor, GCP-1, MDNCF, MONAP, NAP-1
- WB
Supplier Data
Western blot - Anti-IL-8 antibody [807] (AB18672)
This image was produced useing a version of the antibody producted in ascites.
All lanes:
Western blot - Anti-IL-8 antibody [807] (ab18672) at 0.1 µg/mL
All lanes:
recombinant human IL8, 100 ng
Predicted band size: 11 kDa
false
- WB
CiteAb
Western blot - Anti-IL-8 antibody [807] (AB18672)
IL-8 western blot using anti-IL-8 antibody [807] ab18672. Publication image and figure legend from Zhou, X., Lu, H., et al., 2020, Cell Mol Biol Lett, PubMed 32082390.
ab18672 was used in this publication in western blot. This may not be the same as the application(s) guaranteed by Abcam. For a full list of applications guaranteed by Abcam for ab18672 please see the product overview.
MiR-429 inhibited the NF-κB pathway. a, c and e – Relative mRNA expression of NF-κB-regulated genes in SH-SY5Y (a), SK-N-SH (c) and IMR-32 (e) cells. GAPDH was used as a loading control. b, d and f – Western blot showing NF-κB-regulated gene protein expression levels in SH-SY5Y (b), SK-N-SH (d) and IMR-32 (f) cells. g and h – Overexpression of IKKβ attenuated the anticancer effect of miR-429 in SH-SY5Y and SK-N-SH cells. Error bars represent the mean ± SEM of at least three independent experiments. N.S. : not significant; *p < 0.05 and **p < 0.01 vs. the control group
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Reactivity data
Product details
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
IL-8 functions as a chemoattractant for neutrophils and lymphocytes facilitating their movement towards the site of infection or injury. It does not form part of a larger protein complex but operates individually to enhance immune cell migration. IL-8 possesses unique binding motifs allowing it to interact with specific receptors namely CXCR1 and CXCR2 on target cells. This binding triggers cellular responses leading to effective immune surveillance and response to inflammatory stimuli.
Pathways
IL-8 operates within important inflammatory and immune response pathways. It forms a part of the NF-κB signaling cascade which activates in response to stress signals promoting the expression of other inflammatory mediators. Additionally it engages in the mitogen-activated protein kinase (MAPK) pathway influencing cellular responses such as proliferation and differentiation. The interaction of IL-8 with these pathways highlights its role in modulating immune responses and highlights its interaction with other proteins such as TNF-α and IL-1β.
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Target data
Publications (71)
Recent publications for all applications. Explore the full list and refine your search
Nature communications 16:2229 PubMed40044657
2025
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Medicine 103:e39458 PubMed39465852
2024
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Molecular cell 84:3271-3287.e8 PubMed39178863
2024
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Scientific reports 14:19078 PubMed39154102
2024
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British journal of cancer 131:271-282 PubMed38862740
2024
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Cytotechnology 76:97-111 PubMed38304623
2024
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Biomedical optics express 15:185-198 PubMed38223184
2024
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Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2303489 PubMed37964763
2023
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Cell death & disease 14:725 PubMed37938546
2023
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BMC immunology 24:4 PubMed36650424
2023
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Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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