AB106278

Anti-IL1 Receptor I/IL-1R-1 antibody

Name: Anti-IL1 Receptor I/IL-1R-1 antibody (ab106278) | Abcam
Brand: Abcam Limited
SKU: AB106278
Price: 450 USD
Availability: InStock
Rating: 3 (3 reviews)

(3 Reviews)

(37 Publications)

Anti-IL1 Receptor I/IL-1R-1 antibody (ab106278) is a rabbit polyclonal antibody detecting IL1 Receptor I/IL-1R-1 in Western Blot, IHC-P. Suitable for Human.

- Over 20 publications

View Alternative Names

CD121a, IL1R, IL1RA, IL1RT1, IL1R1, Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1, IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, Interleukin-1 receptor type I, p80, IL-1R-alpha

2 Images

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Western blot - Anti-IL1 Receptor I/IL-1R-1 antibody (AB106278)

All lanes:

Western blot - Anti-IL1 Receptor I/IL-1R-1 antibody (ab106278) at 1/500 dilution

Lane 1:

Human fetal spleen lysate

Lane 2:

HeLa (Human epithelial cell line from cervix adenocarcinoma) cell lysate

Predicted band size: 65 kDa

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL1 Receptor I/IL-1R-1 antibody (AB106278)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL1 Receptor I/IL-1R-1 antibody (AB106278)

ab106278 used at 1/100 dilution staining IL-1 Receptor 1 / IL-1R-1 in fetal human epithelial skin tissue by immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human IL1R1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

P14778

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Product details

What is this antibody validated in?
Anti-IL1 Receptor I/IL-1R-1 antibody (ab106278) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human samples.

What is the molecular weight of IL1 Receptor I/IL-1R-1?
Anti-IL1 Receptor I/IL-1R-1 (ab106278) specifically detects a band for IL1 Receptor I/IL-1R-1 (UniProt: P14778) at a molecular weight of 65kDa.

Trusted by the scientific community
Anti-IL1 Receptor I/IL-1R-1 (ab106278) was first used in a scientific publication in 2011 and has been cited over 20 times in peer-reviewed journals.

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Properties and storage information

Form

Lyophilized

Reconstitution

reconstitute with water at 200µL

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IL-1 Receptor I also known as IL-1R1 is a transmembrane protein with alternative names such as IL-1 receptor and IL-1 type I receptor. It acts as an important receptor for the pro-inflammatory cytokine Interleukin-1 (IL-1) family primarily IL-1α and IL-1Β. IL-1R1 has a mass of approximately 80 kilodaltons and is expressed in a variety of cell types including endothelial cells epithelial cells and fibroblasts. It is also present on immune cells like monocytes and macrophages making it widespread in a vast range of tissues.

Biological function summary

IL-1R1 is a critical player in the initiation of immune responses serving as a component of the IL-1 signaling complex. When IL-1 binds to IL-1R1 it recruits the IL-1 receptor accessory protein (IL-1RAcP) to form a signaling complex that triggers downstream pathways. This interaction initiates a signaling cascade that activates nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) promoting the expression of inflammatory genes and mediating immune and inflammatory responses.

Pathways

IL-1R1 is central to the inflammatory response and immune signaling pathways. The IL-1 receptor complex facilitates the activation of NF-κB which plays a role in the body's response to stress cytokines and pathogens. The receptor acts in close relation with other proteins like IL-1RAcP and IRAKs (Interleukin-1 receptor-associated kinases) in these pathways creating a robust immune signaling network that drives the inflammatory response.

IL-1R1 is closely associated with inflammatory conditions such as rheumatoid arthritis and inflammatory bowel disease. Increased IL-1R1 expression and signaling contribute to chronic inflammation in these diseases. The interaction of IL-1Β with IL-1R1 and subsequently with proteins like NF-κB leads to the persistence of inflammatory signals. Moreover targeting IL-1R1 and related proteins offers potential therapeutic strategies in mitigating the symptoms and progression of inflammatory disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for IL1A, IL1B and IL1RN (PubMed : 2950091, PubMed : 37315560). After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed : 10653850).

See full target information IL1R1

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Publications (37)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:113305 PubMed40894877

2025

Elaidic acid drives cellular senescence and inflammation via lipid raft-mediated IL-1R signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Ryota Kojima,Yusuke Hirata,Ryo Ashida,Miki Takahashi,Ryosuke Matsui,Kotaro Hama,Ayako Watanabe,Ryo Takita,Emiko Sato,Taiki Abe,Kazuaki Yokoyama,Takuya Noguchi,Atsushi Matsuzawa

Frontiers in immunology 16:1571007 PubMed40852727

2025

Therapeutic potential of formononetin in cirrhotic portal hypertension: modulating hepatic fibrosis, macrophage polarization, and lymphangiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenghao Wu,Guqing Luo,Hongjie Li,Min Chen,Guangbo Wu,Qiang Fan,Chihao Zhang,Jiwei Yu,Jiayun Lin,Jinbo Zhao,Xiaoliang Qi,Haizhong Huo,Meng Luo,Lei Zheng

Biomolecules 15: PubMed40305345

2025

Link N Directly Targets IL-1β to Suppress Inflammation and Regulate Sensory Pain in Intervertebral Disc Degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Michael P Grant,Muskan Alad,Fajer Yousef,Laura M Epure,John Antoniou,Fackson Mwale

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2412574 PubMed39903771

2025

Radiotherapy-Associated Cellular Senescence and EMT Alterations Contribute to Distinct Disease Relapse Patterns in Locally Advanced Cervical Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Zhang,Jun Ma,Jun Zhang,Minjie Hu,Jinlin Cheng,Bin Hu,Junjun Zhou,Di Zhou,Yongrui Bai,Xiumei Ma,Jianming Tang,Haiyan Chen,Ying Jing

eLife 13: PubMed39728924

2024

Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Ananda Kishore Mukherjee,Subhajit Dutta,Ankita Singh,Shalu Sharma,Shuvra Shekhar Roy,Antara Sengupta,Megha Chatterjee,Soujanya Vinayagamurthy,Sulochana Bagri,Divya Khanna,Meenakshi Verma,Dristhi Soni,Anshul Budharaja,Sagar Kailasrao Bhisade,Vivek Anand,Ahmad Perwez,Nija George,Mohammed Faruq,Ishaan Gupta,Radhakrishnan Sabarinathan,Shantanu Chowdhury

International journal of molecular sciences 25: PubMed39518962

2024

Gestational Diabetes Mellitus-Induced Inflammation in the Placenta via IL-1β and Toll-like Receptor Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Katarzyna Zgutka,Marta Tkacz,Patrycja Tomasiak,Katarzyna Piotrowska,Przemysław Ustianowski,Andrzej Pawlik,Maciej Tarnowski

Cancer research 85:477-496 PubMed39531510

2024

Ferroptotic Neutrophils Induce Immunosuppression and Chemoresistance in Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Wenfeng Zeng,Ruihua Zhang,Penghan Huang,Minxia Chen,Houying Chen,Xin Zeng,Jiang Liu,Jiahui Zhang,Di Huang,Liyan Lao

Bioactive materials 25:307-318 PubMed36844362

2023

Regulating macrophage-MSC interaction to optimize BMP-2-induced osteogenesis in the local microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Jiang,Xuanyu Qi,Xiaolin Wu,Sihan Lin,Junfeng Shi,Wenjie Zhang,Xinquan Jiang

Frontiers in genetics 13:1036233 PubMed36468014

2022

Transcriptome profiling of abdominal aortic tissues reveals alterations in mRNAs of Takayasu arteritis.

Applications

Unspecified application

Species

Unspecified reactive species

Miao Yuqing,Gao Shang,Gao Qing,Wang Jiyang,Li Ruihao,Chen Zuoguan,Diao Yongpeng,Wu Zhiyuan,Li Yongjun

Bioengineered 13:13452-13461 PubMed35659191

2022

Suppression of long intergenic non-protein coding RNA 1123 constrains lower extremity deep vein thrombosis via microRNA-125a-3p to target interleukin 1 receptor type 1.

Applications

Unspecified application

Species

Unspecified reactive species

Baocai Yang,ZiXiang Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-IL1 Receptor I/IL-1R-1 antibody

Western blot - Anti-IL1 Receptor I/IL-1R-1 antibody (AB106278)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL1 Receptor I/IL-1R-1 antibody (AB106278)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Reconstitution

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (37)

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