AB233792

Anti-IL2 Receptor beta/p75 antibody [1G11C6]

Name: Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792) | Abcam
Brand: Abcam Limited
SKU: AB233792
Price: 495 USD
Availability: InStock

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(1 Publication)

Mouse Monoclonal IL2 Receptor beta/p75 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human IL2RB aa 1-250.

View Alternative Names

CD122, IL15RB, IL2RB, Interleukin-2 receptor subunit beta, IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, High affinity IL-2 receptor subunit beta, Interleukin-15 receptor subunit beta, p70-75, p75

4 Images

Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (AB233792)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (AB233792)

Flow cytometric analysis of Jurkat (human T cell leukemia cell line from peripheral blood) cells labeling IL2 Receptor beta/p75 with ab233792 at 1/200 dilution (green) compared with a negative control (red).

Flow Cyt

Supplier Data

Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (AB233792)

Flow cytometric analysis of HL-60 (human promyelocytic leukemia cell line) cells labeling IL2 Receptor beta/p75 with ab233792 at 1/200 dilution (green) compared with a negative control (red).

Supplier Data

Western blot - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (AB233792)

Expected MW is 51kDa.

All lanes:

Western blot - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792) at 1/500 dilution

All lanes:

Recombinant human IL2 Receptor beta/p75 (aa 27-240) protein

Predicted band size: 61 kDa

false

Supplier Data

Western blot - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (AB233792)

All lanes:

Western blot - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (ab233792) at 1/500 dilution

Lane 1:

Untransfected HEK-293 (human epithelial cell line from embryonic kidney) cell lysate

Lane 2:

IL2 Receptor beta/p75 (aa 27-240)-hIgG-Fc-transfected HEK-293 cell lysate

Predicted band size: 61 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

1G11C6

Isotype

IgG2b

Carrier free

Reacts with

Human

Applications

WB, Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human IL2RB aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

P14784

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/200 - 1/400", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cynomolgus monkey": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purified from tissue culture supernatant.

Storage buffer

Preservative: 0.05% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IL2 Receptor beta also known as IL-2R beta IL2R beta or CD122/IL2RB protein is a component of the interleukin-2 receptor complex. It is part of the receptor system for the cytokine IL-2. This receptor subunit has a molecular mass of approximately 75 kDa and gets alternatively referred to as IL2R beta or p75. It is expressed on the surface of activated T cells natural killer (NK) cells and in some cases myeloid lineage cells. This expression pattern correlates IL2R beta's role in essential immune functions and signaling processes.

Biological function summary

IL2R beta plays a critical role in cytokine binding and signal transduction for the interleukin-2 receptor which is a heterodimeric complex. This complex consists of the IL-2 receptor alpha (CD25) IL-2 receptor beta and a common gamma chain (γc CD132). The presence of IL-2R beta allows the receptor to mediate biological processes like cell proliferation differentiation and survival particularly within the immune system. The extent to how IL2R beta integrates into these processes makes it an important player in immune regulation and homeostasis.

Pathways

IL2R beta serves essential functions in the JAK-STAT and PI3K-AKT pathways. The binding of IL-2 to its receptor initiates a cascade of intracellular events which involve Janus kinases (JAKs) and signal transducer and activator of transcription (STATs) leading to transcriptional activation of various genes. Along with these pathways IL2R beta also interacts collaboratively with the gamma chain (γc) in promoting Downstream signaling events which enhance cell proliferation and survival.

IL2R beta's function has implications in autoimmune diseases and certain types of leukemia. Alterations or dysregulation in IL-2R signaling pathways often play a role in autoimmune conditions due to its importance in maintaining immune tolerance. Moreover given IL-2 receptor's role in T-cell and NK-cell activity aberrations may contribute to uncontrolled cellular proliferation seen in leukemia. Understanding its interplay with the common gamma chain (CD132) can provide insights into therapeutic interventions targeting these disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed : 15123770, PubMed : 31040185).

See full target information IL2RB

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Kidney international 81:458-68 PubMed22166849

2011

Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Leyi Gu,Xinyue Liang,Lihua Wang,Yucheng Yan,Zhaohui Ni,Huili Dai,Jiayuan Gao,Shan Mou,Qin Wang,Xinyu Chen,Liming Wang,Jiaqi Qian

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-IL2 Receptor beta/p75 antibody [1G11C6]

Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (AB233792)

Flow Cytometry - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (AB233792)

Western blot - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (AB233792)

Western blot - Anti-IL2 Receptor beta/p75 antibody [1G11C6] (AB233792)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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