Rabbit Polyclonal ILP2 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human BIRC8 aa 1-50.
Images
Publications
Filter by
- Molecular medicine reports 25:2022Proteomic analysis of inhibitor of apoptosis protein‑like protein‑2 on breast cancer cell proliferation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSiqi Xiang,Lin Zhu,Zhiliang Zhang,Siyuan Wang,Ruxia Cui,Mingjun XiangPubMed 35039877
- Experimental and therapeutic medicine 22:10062021Overexpression of HOXD8 inhibits the proliferation, migration and invasion of breast cancer cells by downregulating ILP2 expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoyun Wen,Yu Chen,Xiansong FangPubMed 34345288
- eLife 10:2021Deficient spermiogenesis in mice lacking .Applications:Unspecified applicationReactive species:Unspecified reactive speciesFeng Wang,Maria Gracia Gervasi,Ana Bošković,Fengyun Sun,Vera D Rinaldi,Jun Yu,Mary C Wallingford,Darya A Tourzani,Jesse Mager,Lihua Julie Zhu,Oliver J Rando,Pablo E Visconti,Lara Strittmatter,Ingolf BachPubMed 33620316
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34:10531-105462020BML-111 treatment prevents cardiac apoptosis and oxidative stress in a mouse model of autoimmune myocarditis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRafael I Jaén,María Fernández-Velasco,Verónica Terrón,Sergio Sánchez-García,Carlos Zaragoza,Natalia Canales-Bueno,Almudena Val-Blasco,María Teresa Vallejo-Cremades,Lisardo Boscá,Patricia PrietoPubMed 32543747
- The Journal of clinical investigation 130:2054-20682020Neogenin neutralization prevents photoreceptor loss in inherited retinal degeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJason Charish,Alireza P Shabanzadeh,Danian Chen,Patrick Mehlen,Santhosh Sethuramanujam,Hidekiyo Harada,Vera L Bonilha,Gautam Awatramani,Rod Bremner,Philippe P MonnierPubMed 32175920
- Scientific reports 10:46252020Tead transcription factors differentially regulate cortical development.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTanzila Mukhtar et. al.PubMed 32170161
- Experimental and therapeutic medicine 17:4687-46922019Protective effects of Asiatic acid against pelvic inflammatory disease in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDejia Kong et. al.PubMed 31086602
- Oncology reports 40:2047-20552018Inhibitor of apoptosis protein‑like protein‑2: A novel growth accelerator for breast cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLin Zhu,Weihua Zhou,Xidi Zhu,Siqi Xiang,Siyuan Wang,Yingxia Peng,Bangyun Lu,Peizhi Tang,Qian Chen,Mengjuan Wu,Xia Peng,Ziyu Chen,Ziyi Sun,Kunliang Yang,Mingjun Xiang,Dandan YuPubMed 30106449
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human BIRC8 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link Q96P09
Reactivity data
Select an application| ICC | WB | |
|---|---|---|
| Human | Tested | Tested |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10 µg/mL | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1.00000-2.00000 µg/mL | Notes - |
Alternative names
ILP2, BIRC8, Baculoviral IAP repeat-containing protein 8, Inhibitor of apoptosis-like protein 2, Testis-specific inhibitor of apoptosis, IAP-like protein 2, ILP-2
Recommended products
Rabbit Polyclonal ILP2 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human BIRC8 aa 1-50.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human BIRC8 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link Q96P09
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein ILP2 also known as Inhibitor of Apoptosis Protein 2 plays an important role mechanically by acting as an apoptotic suppressor. ILP2's estimated molecular mass is approximately 32 kDa. Expression mostly occurs in testicular tissues though traces are present in other tissues. ILP2 shares structural and functional similarities with other members of the inhibitor of apoptosis protein (IAP) family which allow it to interact closely with various cellular components.
- Biological function summary
The protein functions by preventing cell death providing essential support for cellular survival. ILP2 is part of a complex that includes other IAPs and operates in the regulation of apoptosis. Its action directly inhibits caspases which are enzymes critical for the execution phase of cell apoptosis. This function is significant as it contributes to the balance between cell proliferation and death making ILP2 an important player in cellular homeostasis.
- Pathways
The protein acts in critical signaling pathways related to cell survival and apoptosis like the NF-kB signaling pathway. ILP2 works in conjunction with proteins such as XIAP and c-IAP1 which participate in similar pathways contributing to protection against unwanted cell death. This involvement helps maintain normal cellular processes and supports proper functioning of tissues.
- Associated diseases and disorders
The protein ILP2 has been implicated in different malignancies including testicular cancer and some leukemia forms. ILP2 may lead to disease progression by preventing apoptosis which allows cancer cells to survive longer than they should. In these diseases ILP2 often interacts with other apoptosis inhibitors like XIAP and Survivin increasing the complexity of the therapeutic targets associated with cancer treatment.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Western blot - Anti-ILP2 antibody (ab9664)
All lanes: Western blot - Anti-ILP2 antibody (ab9664) at 1 µg/mL
Lane 1: HepG2 cell lysate
Lane 2: MOLT4 cell lysate
Predicted band size: 27 kDa
Immunocytochemistry - Anti-ILP2 antibody (ab9664)
ab9664 at 10μg/ml staining ILP2 in HepG2 cells by Immunocytochemistry.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com