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AB231813

Anti-ILT-3 antibody

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(2 Publications)

Rabbit Polyclonal ILT-3 antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Lilrb4a aa 1 to C-terminus.

View Alternative Names

CD85k, Gp49b, Lilrb4a, Leukocyte immunoglobulin-like receptor subfamily B member 4A, Mast cell surface glycoprotein Gp49B

2 Images
Western blot - Anti-ILT-3 antibody (AB231813)
  • WB

Supplier Data

Western blot - Anti-ILT-3 antibody (AB231813)

All lanes:

Western blot - Anti-ILT-3 antibody (ab231813) at 2 µg/mL

All lanes:

Rat adrenal gland tissue

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit at 1/2000 dilution

Predicted band size: 49 kDa

false

Western blot - Anti-ILT-3 antibody (AB231813)
  • WB

Supplier Data

Western blot - Anti-ILT-3 antibody (AB231813)

All lanes:

Western blot - Anti-ILT-3 antibody (ab231813) at 2 µg/mL

All lanes:

Recombinant mouse ILT-3 protein

Predicted band size: 49 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Mouse Lilrb4a aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q64281

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ILT-3 also known as Immunoglobulin-like transcript 3 is a protein predominantly expressed on dendritic cells and monocytes. It is a type I transmembrane protein belonging to the leukocyte immunoglobulin-like receptor family. The ILT-3 protein has a molecular mass of approximately 60 kDa. In addition to its presence on dendritic cells and monocytes ILT-3 can be detected in low levels on some types of macrophages. It plays a regulatory role in the immune system which can influence how the body responds to pathogens and tissue damage.
Biological function summary

ILT-3 acts as an inhibitory receptor that modulates immune responses. It is often linked with the control of T cell activation and the maintenance of immune tolerance. ILT-3 does not form part of a larger protein complex. Its inhibitory function helps in preventing overactivation of the immune system by modulating the signaling pathways necessary for immune response. This modulation occurs through ITIM (Immunoreceptor Tyrosine-based Inhibitory Motif) domains that recruit phosphatases helping in dephosphorylating key signaling proteins and aiding in downregulation of immune cell activities.

Pathways

The ILT-3 protein is involved in important immune regulatory pathways contributing significantly to the immune checkpoint pathway. It interacts with other immunoglobulin-like receptors and is known to influence pathways involving PD-1 (Programmed cell death protein 1) and CTLA-4 (Cytotoxic T-lymphocyte-associated protein 4). By affecting these pathways ILT-3 serves as a checkpoint that ensures immune homeostasis prevents excess inflammation and influences the balance between immune activation and suppression within the body.

ILT-3 has been implicated in autoimmune diseases and transplant rejection. It helps in suppressing immune responses that can lead to conditions like rheumatoid arthritis and could negatively affect organ transplant outcomes by minimizing the chance of rejection. ILT-3's role in these conditions connects it to proteins such as HLA-G and PD-L1 which are also involved in immune modulation and contribute to disease pathogenesis. Understanding ILT-3’s role provides insights into potential therapeutic targets for these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibitory receptor involved in the down-regulation of the immune response (PubMed : 10026201, PubMed : 24935931). Receptor for FN1 (PubMed : 34089617). Receptor for integrin ITGAV/ITGB3 (PubMed : 11323698). Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3 (PubMed : 10026201, PubMed : 11323698, PubMed : 11457897, PubMed : 8855262). Also inhibits KITLG/SCF-mediated mast cell activation (PubMed : 12884301). Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells (PubMed : 24935931). Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells (PubMed : 12682239). Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation (PubMed : 18792399). Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury (PubMed : 14557414). Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation (PubMed : 17761953). Inhibits lysis by natural killer cells (PubMed : 8977169).
See full target information Lilrb4a
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Translational oncology 56:102381 PubMed40199156

2025

Tumor-derived immunoglobulin-like transcript 3 inhibition reshapes the immunosuppressive tumor microenvironment and potentiates programmed cell death ligand 1 blockade immunotherapy in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Leirong Wang,Qing Li,Yanxin Sun,Shuyun Wang,Xuebing Fu,Xiufen Wang,Yan Zheng,Aiqin Gao,Yuping Sun,Juan Li

Frontiers in oncology 10:1226 PubMed32850364

2020

Deregulation of Polycomb Repressive Complex-2 in Mantle Cell Lymphoma Confers Growth Advantage by Epigenetic Suppression of .

Applications

Unspecified application

Species

Unspecified reactive species

Christos Demosthenous,Shiv K Gupta,Jing Sun,Yongsen Wang,Tammy P Troska,Mamta Gupta
View all publications
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