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AB111703

Anti-ILT-7 antibody

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(1 Publication)

Rabbit Polyclonal ILT-7 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LILRA4 aa 1-250.

View Alternative Names

CD85g, ILT7, LILRA4, Leukocyte immunoglobulin-like receptor subfamily A member 4, CD85 antigen-like family member G, Immunoglobulin-like transcript 7, ILT-7

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ILT-7 antibody (AB111703)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ILT-7 antibody (AB111703)

ab111703 at 1/500 dilution staining ILT-7 in Formalin-fixed, paraffin-embedded Human Breast carcinoma tissue.

Western blot - Anti-ILT-7 antibody (AB111703)
  • WB

Unknown

Western blot - Anti-ILT-7 antibody (AB111703)

10% SDS-PAGE.

All lanes:

Western blot - Anti-ILT-7 antibody (ab111703) at 1/1000 dilution

All lanes:

Raji whole cell lysate at 30 µg

Predicted band size: 55 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human LILRA4 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

P59901

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ILT-7 also known as LILRA4 is an important receptor involved in the immune response. It is expressed on plasmacytoid dendritic cells and holds significant weight approximately 38 kDa. The receptor is part of the immunoglobulin-like transcript family containing unique extracellular domains that interact with specific ligands. ILT-7 is known for its role in mediating signals that shape the behavior of immune cells particularly in antiviral defenses.
Biological function summary

ILT-7 plays an important role in the regulation of type I interferon production in dendritic cells. This receptor forms a complex with the Fc epsilon RI gamma chain which transmits activation signals inside the cell. In resting conditions ILT-7 helps maintain immune homeostasis by regulating the release of interferons therefore balancing immune activation and controlling potential overactivity that might lead to autoimmunity.

Pathways

ILT-7 interacts within the signaling network of toll-like receptor (TLR) pathways. It closely ties with TLR9 a protein that recognizes unmethylated CpG motifs often found in viral DNA enhancing the production of interferons during viral infections. This collaboration establishes a link between pathogen recognition and immune response modulation within dendritic cells assisting in orchestrating a potent defense against viral pathogens.

ILT-7 has connections to systemic lupus erythematosus and chronic viral infections. Dysregulation of ILT-7 expression or function can lead to excessive interferon production contributing to the pathology of lupus. In chronic viral infections ILT-7 interaction with proteins like TLR9 and the subsequent dysregulation can support viral persistence or worsen disease outcomes by altering immune responses. Understanding ILT-7’s roles offers insights into therapeutic targets for modulating immune response in these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed : 16735691, PubMed : 19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades (PubMed : 16735691, PubMed : 19564354, PubMed : 24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed : 26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed : 16735691, PubMed : 19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed : 24586760).
See full target information LILRA4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 293:8077-8088 PubMed29622675

2018

Sorting nexin 9 (SNX9) regulates levels of the transmembrane ADAM9 at the cell surface.

Applications

Unspecified application

Species

Unspecified reactive species

Kasper J Mygind,Theresa Störiko,Marie L Freiberg,Jacob Samsøe-Petersen,Jeanette Schwarz,Olav M Andersen,Marie Kveiborg
View all publications
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