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AB272558

Anti-IMPG2 antibody

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Rabbit Polyclonal IMPG2 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human IMPG2 aa 1100 to C-terminus.

View Alternative Names

IPM200, IMPG2, Interphotoreceptor matrix proteoglycan 2, Interphotoreceptor matrix proteoglycan of 200 kDa, Sialoprotein associated with cones and rods proteoglycan, IPM 200, Spacrcan

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IMPG2 antibody (AB272558)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IMPG2 antibody (AB272558)

Paraffin-embedded formalin-fixed human retina tissue stained for IMPG2 using ab272558 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IMPG2 antibody (AB272558)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IMPG2 antibody (AB272558)

Paraffin-embedded formalin-fixed human liver tissue stained for IMPG2 using ab272558 at 1/500 dilution in immunohistochemical analysis. No positive staining observed.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IMPG2 antibody (AB272558)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IMPG2 antibody (AB272558)

Paraffin-embedded formalin-fixed human pancreas tissue stained for IMPG2 using ab272558 at 1/500 dilution in immunohistochemical analysis. No positive staining observed.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IMPG2 antibody (AB272558)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IMPG2 antibody (AB272558)

Paraffin-embedded formalin-fixed human kidney tissue stained for IMPG2 using ab272558 at 1/500 dilution in immunohistochemical analysis. No positive staining observed.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human IMPG2 aa 1100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BZV3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IMPG2 also known as Interphotoreceptor Matrix Proteoglycan 2 plays an essential role in the structural makeup of the interphotoreceptor matrix. It acts as a proteoglycan characterized by a high molecular weight of approximately 123 kDa. This protein is predominantly expressed in the retina particularly within the retinal photoreceptor cells. Its mechanical function involves interacting with other components of the matrix contributing to the stability and maintenance of the structure.
Biological function summary

IMPG2 supports photoreceptor cell function by maintaining the gel-like environment necessary for correct photoreceptor activity. It is a part of the matrix complex providing a supportive scaffold for cellular and molecular interactions. The presence of this protein enhances the efficiency of nutrient exchange between the retinal pigment epithelium and photoreceptor cells which is critical for phototransduction and overall retinal health.

Pathways

The function of IMPG2 integrates into the visual perception pathway and phototransduction pathway. Its role involves interactions with opsin proteins which are critical for initiating visual signal transduction. Additionally IMPG2 is associated with rhodopsin an important visual pigment in these pathways supporting its structural and functional stability within the retinal environment.

IMPG2 relates significantly to retinitis pigmentosa and vitelliform macular dystrophy. Mutations in the IMPG2 gene contribute to the degenerative processes observed in these retinal diseases. In the context of retinitis pigmentosa IMPG2's interactions with proteins like peripherin-2 help explain the phenotype of the disorder. In vitelliform macular dystrophy an impaired IMPG2 protein disrupts matrix composition affecting visual outcomes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin.
See full target information IMPG2
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