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AB221063

Anti-IMUP antibody

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(3 Publications)

Rabbit Polyclonal IMUP antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human IMUP aa 1-100.

View Alternative Names

C19orf33, IMUP, Immortalization up-regulated protein, Hepatocyte growth factor activator inhibitor type 2-related small protein, H2RSP, HAI-2-related small protein

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-IMUP antibody (AB221063)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-IMUP antibody (AB221063)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized PC3 cells labeling IMUP with ab221063 at 4 μg/mL (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human IMUP aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9GZP8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IMUP protein also known as C19orf33 has a molecular weight of approximately 17 kDa. This small protein is expressed in various tissues across the human body with noticeable levels in immune-related tissues like the spleen and lymph nodes. The specific cellular localization and expression patterns suggest a role in the immune system's functions. Researchers frequently investigate it to understand its potential interactions and effects better.
Biological function summary

IMUP participates in immune system regulation and cellular processes. It does not operate alone but forms part of a protein complex that influences immune responses. This complex is critical in recognizing and responding to foreign antigens aiding the immune system in distinguishing between self and non-self entities. The protein's involvement in cellular signaling pathways indicates its role in managing cell communication and response to environmental changes.

Pathways

The IMUP protein plays roles within immune signaling and inflammatory pathways. For example immune response pathways such as the NF-kB pathway involve IMUP as a modulator. Proteins like TNF-alpha interact closely with IMUP influencing its role in signaling processes that regulate inflammation and cellular survival. These interactions highlight its importance in immune response regulation and complex signaling networks.

IMUP is associated with autoimmune diseases and chronic inflammatory conditions. Researchers have identified its altered expression in autoimmune disorders such as rheumatoid arthritis where it's implicated in the disease's pathogenesis. It interacts with proteins like IL-6 which are known to contribute to the inflammatory environment characteristic of these conditions. Understanding IMUP's involvement in such diseases may offer insights into potential therapeutic targets and treatment strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information IMUP
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nature 626:1116-1124 PubMed38355802

2024

Autonomous transposons tune their sequences to ensure somatic suppression.

Applications

Unspecified application

Species

Unspecified reactive species

İbrahim Avşar Ilık,Petar Glažar,Kevin Tse,Björn Brändl,David Meierhofer,Franz-Josef Müller,Zachary D Smith,Tuğçe Aktaş

Cell biology and toxicology 39:2069-2087 PubMed35142956

2022

Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.

Applications

Unspecified application

Species

Unspecified reactive species

Qiankun Luo,Yanfeng Pan,Qiang Fu,Xu Zhang,Shuai Zhou,Pengfei Yu,Huiyuan Tian,Pan Liu,Song Chen,Hongwei Zhang,Tao Qin

Cancer cell international 21:620 PubMed34819098

2021

IMUP and GPRC5A: two newly identified risk score indicators in pancreatic ductal adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Rong Wei,Guoye Qi,Zixin Zeng,Ningning Shen,Ziyue Wang,Honghong Shen,Lifang Gao,Chen Song,Wenxia Ma,Chen Wang
View all publications
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