JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB228823

Anti-IMUP antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal IMUP antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human IMUP aa 1-50.

View Alternative Names

C19orf33, IMUP, Immortalization up-regulated protein, Hepatocyte growth factor activator inhibitor type 2-related small protein, H2RSP, HAI-2-related small protein

1 Images
Western blot - Anti-IMUP antibody (AB228823)
  • WB

Supplier Data

Western blot - Anti-IMUP antibody (AB228823)

Lysates were prepared using NETN lysis buffer.

All lanes:

Western blot - Anti-IMUP antibody (ab228823) at 1/1000 dilution

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg

Lane 3:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg

Lane 4:

TCMK-1 (mouse kidney epithelial cell line) whole cell lysate at 50 µg

Lane 5:

NIH/3T3 (mouse embryo fibroblast cell line) whole cell lysate at 50 µg

Predicted band size: 11 kDa

true

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human IMUP aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q9GZP8

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab228823 was affinity purified using an epitope specific to IMUP immobilized on solid support.
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IMUP protein also known as C19orf33 has a molecular weight of approximately 17 kDa. This small protein is expressed in various tissues across the human body with noticeable levels in immune-related tissues like the spleen and lymph nodes. The specific cellular localization and expression patterns suggest a role in the immune system's functions. Researchers frequently investigate it to understand its potential interactions and effects better.
Biological function summary

IMUP participates in immune system regulation and cellular processes. It does not operate alone but forms part of a protein complex that influences immune responses. This complex is critical in recognizing and responding to foreign antigens aiding the immune system in distinguishing between self and non-self entities. The protein's involvement in cellular signaling pathways indicates its role in managing cell communication and response to environmental changes.

Pathways

The IMUP protein plays roles within immune signaling and inflammatory pathways. For example immune response pathways such as the NF-kB pathway involve IMUP as a modulator. Proteins like TNF-alpha interact closely with IMUP influencing its role in signaling processes that regulate inflammation and cellular survival. These interactions highlight its importance in immune response regulation and complex signaling networks.

IMUP is associated with autoimmune diseases and chronic inflammatory conditions. Researchers have identified its altered expression in autoimmune disorders such as rheumatoid arthritis where it's implicated in the disease's pathogenesis. It interacts with proteins like IL-6 which are known to contribute to the inflammatory environment characteristic of these conditions. Understanding IMUP's involvement in such diseases may offer insights into potential therapeutic targets and treatment strategies.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

See full target information IMUP
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell biology and toxicology 39:2069-2087 PubMed35142956

2022

Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.

Applications

Unspecified application

Species

Unspecified reactive species

Qiankun Luo,Yanfeng Pan,Qiang Fu,Xu Zhang,Shuai Zhou,Pengfei Yu,Huiyuan Tian,Pan Liu,Song Chen,Hongwei Zhang,Tao Qin
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB221063

Anti-IMUP antibody

Immunocytochemistry/ Immunofluorescence - Anti-IMUP antibody (AB221063)

  • 0
  • 0
Primary Antibodies

AB228821

Anti-IMUP antibody - C-terminal

Immunoprecipitation - Anti-IMUP antibody - C-terminal (AB228821)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB228870

Anti-PRRG2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRRG2 antibody (AB228870)

  • 0
  • 0
Primary Antibodies

AB181869

Anti-VAMP2 antibody [EPR12790]

RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-VAMP2 antibody [EPR12790] (AB181869)

  • 5
  • 1
Primary Antibodies

AB228833

Anti-ZNF556 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZNF556 antibody (AB228833)

  • 0
  • 0
Primary Antibodies

AB228574

Anti-ZNF45 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF45 antibody (AB228574)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com