Anti-Infectious Bursal Disease (Standard) (IBD) antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

IBDV targets specific immune cells within the bursa of Fabricius particularly B lymphocytes. By attacking these cells the virus compromises the bird's immune system which plays a central role in the development and differentiation of B cells in chickens. IBDV operates independently rather than as part of a protein complex. The pathogenesis of this virus involves lysis of infected precursor B lymphocytes resulting in a substantial decrease in antibody production.

Pathways

IBDV infection disrupts the normal immune response pathways within the affected bird. The primary pathway involved is the host's adaptive immune response where the virus impairs the humoral immune function. Proteins like VP2 and VP3 of IBDV play significant roles in these pathways affecting the assembly and entry of the virus. Consequently the bird's immune-mediated signaling cascades get disturbed.